P-5-P is intended for those seeking a high strength, "active" or "coenzyme" form of vitamin B6. Vitamin B6 ( P-5-P) is needed for more than 100 enzyme reactions - including healthy hormone balance, magnesium absorption, and homocysteine metabolism.*.

P-5-P is intended for those seeking a high strength, &quot;active&quot; or &quot;coenzyme&quot; form of vitamin B6. Vitamin B6 ( P-5-P) is needed for more than 100 enzyme reactions - including healthy hormone balance, magnesium absorption, and homocysteine metabolism.* Especially for those who eat a mostly vegan or vegetarian diet, B6 supplementation can be very important.&#x2020;<ul id="isPasted"><li style="font-size: 16px;">Active, bioavailable form of vitamin B6</li><li style="font-size: 16px;">Homocysteine metabolism support</li><li style="font-size: 16px;">Supports a healthy mood</li></ul><h4 id="isPasted">Vitamin B6 is an essential nutrient that supports numerous functions in your body.</h4>It&#x2019;s needed to metabolize homocysteine, normalize mood, balance hormones, and help you sleep.&#x2020;Vitamin B6 deficiency has been associated with problems involving the menstrual cycle, heart health, and mood.Unfortunately, many people have trouble converting food sources of vitamin B6 into its active form, known as pyridoxal 5&#x2019;-phosphate or P-5-P. These individuals may benefit from P-5-P dietary supplements.&#x2020;Seeking Health&#x2019;s&#xA0;P-5-P contains a potent 25 mg of vitamin B6 (1,471% Daily Value) in the active form of P-5-P (pyridoxal 5&#x2019;-phosphate).&#x2020;This high-strength vitamin B6 supplement is gluten-free and ideal for those who are deficient or require higher amounts. It can be a great boost to your daily multivitamin or B-complex supplement.&#x2020;P-5-P (pyridoxal 5&#x2019;-phosphate) is considered by many to be the best vitamin B6 form. Vitamin B6 (or pyridoxine) must have a phosphate group attached for it to bind to enzymes.&#xA0;P-5-P is considered an active coenzyme form of vitamin B6. It activates over 140 different enzymatic reactions in the body. Like the other B complex vitamins, you must obtain this water-soluble vitamin daily from food. This is because your body does not make it.&#x2020;Vitamin B6 is required for healthy:&#x2020;<ul><li>Breakdown of amino acids, carbohydrates, and fats</li><li>Energy production/energy metabolism</li><li>Immune system function</li><li>Brain function</li><li>Central nervous system function</li><li>Red blood cells and red blood cell function</li><li>Methylation processes</li><li>Many enzymatic reactions</li></ul>P-5-P pairs well with magnesium to promote healthy female menstrual cycles, neurotransmitter function, and hormone metabolism prior to menstruation. It may also support stomach comfort and digestion due to occasional nausea or morning sickness.&#x2020;It can be challenging to get enough vitamin B6 from foods alone. Seeking Health&#x2019;s&#xA0;P-5-P delivers a high-quality form of vitamin B6 in a convenient capsule. For a complete B complex containing active forms of folate and vitamin B12, consider&#xA0;<a href="https://www.seekinghealth.com/products/b-complex-plus-100-capsules">B Complex Plus</a>.&#x2020;How do I use P-5-P? Suggested Use&#xA0;As needed, take 1 capsule with food anytime of day or night. Use as directed by your healthcare provider. Warnings Consult with your healthcare professional prior to use. Do not use if inner tamper seal is damaged.&#xA0;Suitable for Vegetarians/Vegans&#xA0;Delivery Method Capsules&#xA0;How to Store Keep closed in a cool, dry place out of reach by children.&#xA0;&#x2020;These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Who is P-5-P intended for and how to use?

Ingredient. Purpose. Vitamin B6 (as pyridoxal 5'-phosphate). Supports healthy cognitive development and function, protein and amino acid metabolism, and normal kidney function.†. This active form of vitamin B6 is involved in over 140 different enzyma

&#xA0;<table><tbody><tr><td>Ingredient</td><td>Purpose&#xA0;</td></tr><tr><td>Vitamin B6 (as pyridoxal 5&apos;-phosphate)</td><td>Supports healthy cognitive development and function, protein and amino acid metabolism, and normal kidney function.&#x2020;</td></tr></tbody></table>&#xA0;This active form of vitamin B6 is involved in over 140 different enzymatic reactions in the body. It supports healthy ammonia levels, absorption of magnesium into red blood cells, neurological function, serotonin synthesis and hormone metabolism, as well as homocysteine and glutathione formation.&#x2020;&#xA0;What are the ingredients in P-5-P sourced from? <table border="0" dir="ltr"><tbody><tr><td class="FirstRow FirstCol AdvancedProofingLightMode ContextualSpellingLightMode SpellingErrorLightMode SimilarityReviewedLightMode SimilarityUnreviewedLightMode AddInCritiqueRedLightMode AddInCritiqueGreenLightMode AddInCritiqueBlueLightMode AddInCritiqueLavenderLightMode AddInCritiqueBerryLightMode HighContrastShading SCXW61217704 BCX0" style="width: 50%;">Ingredient&#xA0;</td><td class="FirstRow LastCol AdvancedProofingLightMode ContextualSpellingLightMode SpellingErrorLightMode SimilarityReviewedLightMode SimilarityUnreviewedLightMode AddInCritiqueRedLightMode AddInCritiqueGreenLightMode AddInCritiqueBlueLightMode AddInCritiqueLavenderLightMode AddInCritiqueBerryLightMode HighContrastShading SCXW61217704 BCX0" style="width: 50%;">Source&#xA0;</td></tr><tr><td class="FirstCol LastRow AdvancedProofingLightMode ContextualSpellingLightMode SpellingErrorLightMode SimilarityReviewedLightMode SimilarityUnreviewedLightMode AddInCritiqueRedLightMode AddInCritiqueGreenLightMode AddInCritiqueBlueLightMode AddInCritiqueLavenderLightMode AddInCritiqueBerryLightMode HighContrastShading SCXW61217704 BCX0" style="width: 50%;">Vitamin B6&#xA0;</td><td class="LastCol LastRow AdvancedProofingLightMode ContextualSpellingLightMode SpellingErrorLightMode SimilarityReviewedLightMode SimilarityUnreviewedLightMode AddInCritiqueRedLightMode AddInCritiqueGreenLightMode AddInCritiqueBlueLightMode AddInCritiqueLavenderLightMode AddInCritiqueBerryLightMode HighContrastShading SCXW61217704 BCX0" style="width: 50%;">Synthetic&#xA0;</td></tr></tbody></table> &#x2020;These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

What is the purpose and source of each ingredient in P-5-P?

Does P-5-P contain gluten or grains?. P-5-P is gluten-free. P-5-P does not contain grains. However, this formula contains ascorbyl palmitate which is derived in part from highly purified corn oil. Due to the processes used to manufacture the finished

<table style="width: 100%;"><tbody><tr><td style="width: 50.0000%;">Suitable for&#xA0;</td><td style="width: 50.0000%;">Free of&#xA0;</td></tr><tr><td style="width: 50.0000%;">Bariatric, methyl sensitive, pregnancy, breastfeeding, vegetarian, vegan, ages 4 and up&#xA0; </td><td style="width: 50.0000%;">Dairy, egg, fish, shellfish, tree nuts, peanuts, gluten, soy, sesame. GMOs </td></tr></tbody></table> Does P-5-P contain gluten or grains? P-5-P is gluten-free.&#xA0;P-5-P does not contain grains. However, this formula contains ascorbyl palmitate which is derived in part from highly purified corn oil. Due to the processes used to manufacture the finished ingredients, the final product is free from corn proteins.&#xA0;Is P-5-P free from GMOs? Testing confirms that P-5-P is free from GMO markers.&#xA0;Are there any warnings or side effects when using P-5-P?&#xA0;Warnings Not suitable for children under 4 years of age. For children of any age, please speak with a qualified healthcare professional who can determine an appropriate dose or whether this product is safe for them to take.&#xA0;If you are being treated for any condition or are currently taking any medications, consult with your healthcare professional before considering the use of this product.&#xA0;For pregnant and breastfeeding women, please talk to your qualified healthcare professional before considering the use of this product as this product has not been tested for safety in these groups.&#xA0;Side Effects Side effects of P-5-P may cause:&#xA0;<ul><li>Nausea</li><li>Vomiting</li><li>Stomach pain</li><li>Loss of appetite</li><li>Headache</li><li>Tingling</li><li>Changes in sleep habits&#xA0;</li></ul>If you believe that you are experiencing any adverse reactions, please see your healthcare professional immediately. Each individual may react differently to any product or supplement. We always recommend that you consult with your healthcare professional before considering the use of P-5-P or any supplement.&#xA0;These side-effects are more likely if the recommended dosage is exceeded, if you are taking too high of a dose when first starting, or if taken on an empty stomach. Always take this product with food and in divided doses throughout the day. Dr. Ben Lynch recommends starting with a small dose and only working your way up if needed. He always suggests the Pulse Method as outlined in his book &#x201C;Dirty Genes&#x201D;.&#xA0;

P-5-P Suitability and Allergens

Hi Dana -. According to our quality team, Seeking Health does not have designated kosher supplements. Thank you for asking. Dr. Lynch. Hi Dana -. You may take this anytime of day or night with or without food. I am finding out if it is kosher or not.

<table style="width: 100%;" class="fr-alternate-rows"><tbody><tr><td style="width: 50.0000%;">Question </td><td style="width: 50.0000%;">Answer </td></tr><tr><td style="width: 50.0000%;">Is it kosher? </td><td style="width: 50.0000%;">Hi Dana -According to our quality team, Seeking Health does not have designated kosher supplements.Thank you for asking.Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">P-5-P (Pyridoxal 5-Phosphate) NEET TO TAKE AT MORNING OR NIGHT BEFORE SLEEP? </td><td style="width: 50.0000%;">Hi Dana -You may take this anytime of day or night with or without food.I am finding out if it is kosher or not. I&apos;m not readily certain.Once I know, I&apos;ll let you know.In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Hi. Both our kids have elevated homocysteine, and we are wondering what we can give them to lower it since they have anxiety, and the homocysteine nutrients have methyls. They also both have high lpa, so we are concerned about future cardiac risk with both markers elevated. Please see below for a summary of each child. Inflammation markers, Vitamin D plasma, folate plasma (&gt;20), thyroid, liver/kidney function, and other lipid panels are normal for both. *Teen girl (17 years old): 11.2 homocysteine, 200 lpa (should be less than 75), MTHFR C677T one copy, B12 plasma level closer to top end of range at 1046, B6 plasma level lower than brother&apos;s at 26 (even though they take same multi), eczema, anxiety, ADHD. *Teen boy (16 years old): 11.1 plasma homocysteine, 210 lipoprotein a (should be less than 75), MTHFR C677T one copy, anxiety, ASD and ADHD, B6 plasma levels on top of range at 60.3 (range 3.4-65.2 ug/L), B12 plasma level in the 600-700s range. Any advice would be appreciated. Their homocysteine increased despite taking a digestive enzyme with dinner to help digest nighttime protein for the past year, so that doesn&apos;t seem to have helped. </td><td style="width: 50.0000%;">Hi Justin -I hear you.It&apos;s possible to lower homocysteine using unmethylated nutrients.Consider:<ul><li style="font-size: 12px;">Folinic Acid Lozenge: 1 lozenge upon waking for both of them. Start with 1/2 to see how they do with that. Then they can take the other 1/2 lozenge midday or possibly the whole one in the morning.</li><li style="font-size: 12px;">Glutathione Plus Lozenge: 1/2 lozenge upon waking</li><li style="font-size: 12px;">ProBiota HistaminX: 1 capsule upon waking</li><li style="font-size: 12px;">evaluate how much protein they are getting. They need about 1 gram of protein per pound of body weight. So a 140 lb person needs 140 grams or so.</li></ul>Support healthy LpA levels, consider:*<ul><li style="font-size: 12px;">Fish Oil: 2 caps after dinner</li><li style="font-size: 12px;">CoQ10: 1 capsule after breakfast</li><li style="font-size: 12px;">Acetyl L Carnitine: 1 capsule upon waking and ideally 2 capsules.</li><li style="font-size: 12px;">Niacin: 1 capsule to start - and take after a meal to reduce niacin flushing. Then work up to taking more capsules.* If they do flush, it&apos;s fine. It feels like a warm sensation and can get red dots for about 30 minutes to 1 hour which fade away completely. The more niacin they take over time, the less they will flush. The first few days are the most susceptible to flushing. Taking with food minimizes it. Flushing is a healthy response to niacin - no issues at all.*</li></ul>In health, Dr. Lynch Justin -The digestive enzymes will actually enhance protein absorption which then increases homocysteine.In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Can vitamin b6 with magnesium balance my hormones? I am 35 I have had hypothalamic amenorrhea for 15 years I have not had a period at all for 15 years since I was 20. No one told me it would cause me such serious damage. Estrogen deficiency in the bones. In bone density, I had severe osteoporosis of minus 5. Are my bones in a devastating state, irreversibly destroyed? 15 years without estrogen breaks all the bones in the body? Can new bones be built? </td><td style="width: 50.0000%;">Hi Anat -I recommend working with ElizmaLambert.comThere are many things to evaluate when working with hormones especially when they are low.Food is first and evaluation of absorption issues is second.Highly recommend working with her. Please reach out. :)In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Hello, I&apos;m working with a functional medicine provider to investigate persistent sleep maintenance insomnia. We performed neurotransmitter and salivary cortisol testing through ZRT Labs, and the following markers stood out: Urinary histamine: ~9x above reference range, consistent with histamine intolerance Tryptophan: Low-normal GABA: Below optimal Xanthurenic acid: Elevated, suggesting a functional B6 (pyridoxal-5-phosphate) deficiency Despite adherence to a low-histamine diet and maintaining good sleep hygiene, I continue to wake fully alert between 3:00&#x2013;5:30 AM, with difficulty returning to sleep. Sleep onset is significantly worse following intake of histamine-releasing foods (e.g., chocolate, slow-cooked meats). My provider suspects impaired histamine clearance via the HNMT pathway, likely due to insufficient B6 availability. The plan is to initiate low-dose B6 supplementation (microdosing), as B6 is a required cofactor for HNMT activity. I&#x2019;m otherwise asymptomatic&#x2014;no GI complaints, mood issues, or systemic inflammation&#x2014;and thus, GI testing hasn&#x2019;t been prioritized. I&#x2019;m genetically slow COMT and predisposed to sluggish histamine clearance in general, so I&#x2019;m cautious about introducing supplements that might make me feel overstimulated or worsen sleep. I&#x2019;m also hesitant to take B6 due to concerns about toxicity. My questions are: Would it be advisable to request a serum or plasma B6 (or P5P) from my PCP before supplementing? How can I address the risk of B6 toxicity while still supporting histamine clearance through the HNMT pathway? Should we continue testing beyond neurotransmitter levels (e.g. , mycotoxin, hormonal panel, etc.)? </td><td style="width: 50.0000%;">Hi K -Sleep is key and I hear you that you&apos;re wanting to get that better.High histamine prior to bed is definitely an issue and trigger for insomnia.Vitamin B6 toxicity is not an issue at amounts found in our supplements - also the active form of P5P is less likely to cause an issue compared to pyridoxal HCL and we most commonly use the P5P form.You want to support healthy histamine levels prior to sleep.Here are some things to consider:<ul><li style="font-size: 12px;">Glutathione Plus Lozenge: 1/2 to 1 lozenge upon waking to support healthy methylation so HNMT enzyme and COMT can function.*</li><li style="font-size: 12px;">Optimal Electrolyte: hydration is key for healthy histamine levels and this also has creatine and magnesium which are very important for HNMT and COMT function as well.*</li><li style="font-size: 12px;">ProBiota HistaminX: 1 capsule upon waking in the morning to support healthy histamine levels in the gut which get absorbed and affect the brain.*</li><li style="font-size: 12px;">Histamine Nutrients: 2 capsules before bed to support healthy histamine levels prior to sleep.*</li><li style="font-size: 12px;">Optimal Magnesium: 1 capsule before bed to support healthy COMT function and sleep.*</li><li style="font-size: 12px;">Fish Oil: 1 capsule after dinner to support healthy cell membranes which supports healthy histamine levels.*</li></ul>Trying this for a few days will let you know if this supports healthy duration of sleep or if you need additional support.*If you need additional support for healthy duration of sleep, I have two other suggestions for you to consider:<ul><li style="font-size: 12px;">Adrenal Cortex: 1 capsule after your protein based breakfast to support healthy adrenal function as tired adrenals are a trigger for early waking due to blood sugar irregularities.* I would try this for a few days and if that supports healthy sleep duration, you&apos;re good.*</li><li style="font-size: 12px;">Serotonin Nutrients: 1 capsule before bed to support healthy serotonin levels which support healthy sleep duration.* If the Adrenal Cortex and the above aren&apos;t sufficient, consider adding this in to support healthy sleep duration.*</li></ul>If you&apos;re a woman (sorry - not sure :) ), then low progesterone and high estrogen can be problematic for sleep. So you&apos;d need to support healthy estrogen for this and progesterone.In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">I purchased this B6 and want to know what is the difference between pyridoxal 5-phosphate and Pyridoxine? Is P5P more safe at a dose of 25mg compared to Pyridoxine? 10mg has been recommended as a safe upper tolerable intake and I am wondering if this has something to do with a specific form of B6? </td><td style="width: 50.0000%;">Hi Felicia -The P5P is the active form of B6 while the other one needs to be made into active by the body.B6 should be used, as like any supplement, on an as-needed basis.One doesn&apos;t take B6 in this amount every day for months.They take it to restore healthy levels of B6 and then they pause until they need it again.In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Can kids take this if b6 on oats test is below the means on the oats test? Not flagged as low but right next to it at 1.7 for 8 year old </td><td style="width: 50.0000%;">Hi Alison -I recommend using our Kids Multivitamin Chewable instead as it is more suitable for kids.Give 1 chewable with breakfast.You don&apos;t want to give an excessive amount.In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Al tomar vitamina B6 experimento dolor de cabeza intenso, a&#xFA;n en minimas cantidades, cu&#xE1;l podria ser la causas? Tengo una fuerte intolerancia a las histaminas y azufre, problemas con la metilaci&#xF3;n y una fuerte disbiosis intestinal </td><td style="width: 50.0000%;">When taking vitamin B6 I experience an intense headache, even in minimal quantities, what could be the cause? I have a strong intolerance to histamines and sulfur, problems with methylation and a strong intestinal dysbiosisHi Dei -I am not sure.I suspect your microbiome is using the B6 against you by making chemicals which are aggravating.Consider supporting healthy gut health by using:<ul><li style="font-size: 12px;">Calcium-D-Glucarate: 1 capsule after dinner</li><li style="font-size: 12px;">Molybdenum: 1 capsule with dinner</li><li style="font-size: 12px;">Histamine Digest: 1 capsule with meals</li><li style="font-size: 12px;">ProBiota HistaminX: 1 capsule after dinner</li><li style="font-size: 12px;">Saccharomyces Boulardii: 1 capsule after dinner</li></ul>In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">I&apos;m currently using this product, but I have just heard that B6 accumulates in your body, and excessive amounts can lead to serious problems. This was from several people who did end up with those issues and one was in and out of hospital from a product that contained 12x daily requirement. Could you comment on this, please? Thanks </td><td style="width: 50.0000%;">Hi Callum -Vitamin B6 is water soluble.I&apos;ve talked with some of my colleagues who are more versed in this area than I am.They agree with me that B6 gets blamed for nerve issues but it&apos;s not the cause. It&apos;s associated but it is not causative.High B6 levels are associated with inflammatory processes - so it&apos;s easy to blame.Here are a bunch of papers on B6: <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/vitamin-b6" style=" text-decoration: none;">https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/vitamin-b6</a>In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Hi there,would this be OK to take for histamine and mcas?thanks </td><td style="width: 50.0000%;">Hi Stephanie -I hear that some people do well with the B6 and others do not.Instead of taking a specific B6, I would consider our Multivitamin One MF (we are out of stock until end of May though...)You may use this instead - and it&apos;s surprisingly effective for supporting healthy energy and mood.* <a href="https://www.seekinghealth.com/products/kidss-multivitamin-chewable-mf" style=" text-decoration: none;">https://www.seekinghealth.com/products/kidss-multivitamin-chewable-mf</a>In health, Dr. Lynch </td></tr><tr><td style="width: 50.0000%;">Hi, any idea why P-5-P would cause insomnia worse? I take it in the morning too. </td><td style="width: 50.0000%;">Hi Vicki -I do not know the precise reasons as B6 is used by many enzymes in the human body.I recommend pinpointing that it is in fact the B6 causing this issue for you.It may not be.B6 usually supports healthy sleep.I&apos;d consider our Optimal Magnesium and take 1 capsule before bed to support healthy sleep.In health, Dr. Lynch </td></tr></tbody></table>

P-5-P Dr. Lynch product Q&A

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