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Influencing Factors

Common StrateGene questions

Why Doesn’t StrateGene Offer More Personalized Supplement and Dosage Suggestions (when Other Companies Do?)

The short answer:  It will most likely end up being a waste of your money and time. The long answer:  Your DNA is an important aspect of your current and future health as it is the blueprint to possibilities, but not necessarily certainties. Your die

Why aren't there more precise, individualized recommendations based on genotype for each SNP?

Research that looks at more specific interactions between SNPs and factors like Vitamin E intake, air pollution, exercise or composition of dietary fats is still not that common and tends to be under-powered. One piece of research may appear to settl

Why does my report sometimes have factors that slow or speed up genes, like COMT and CYP1A2, but other genes only have factors that clean and dirty them?

The genes that show factors that slow or speed them up, such as COMT, are somewhat special cases: the SNPs are very common, and each allele has benefits and risk. Knowing what factors can influence speed can be clinically relevant and useful. For exa

What is the difference between a pharmacological dose and a physiological dose?

Dosages of medication, nutrients and vitamins can be categorized in two basic categories: physiological and pharmacological. A very low dose that closely approximates what the body would normally produce in a day is considered physiological. A low do

Which products support each StrateGene Pathway?

*These statements have not been evaluated by the Food and Drug Administration. Seeking Health products are not intended to diagnose, treat, cure, or prevent any disease.

What does high estradiol mean?

In the context of inhibition/promotion or cleans/dirties, high estrogen actually refers to the normal presence of the major estrogen: estradiol relative to no estrogen at all such as before puberty or after menopause. It does not mean hyper-estrogeni

I see some commonly mentioned treatments on the internet are not included in StrateGene treatment considerations. Why is this?

In making treatment suggestions, only evidence based therapies and those found effective by experienced licensed health professionals are included. As we learn new treatments and find them clinically effective, we will update StrateGene accordingly.

What does time and dose -dependent and habituation mean?

Time and dose -dependent is aka dose–response relationship, or exposure–response relationship. It describes the biochemical change in activity of an enzyme caused by differing levels of exposures (or doses) to a system after a defined exposure time.

Why is synthetic folic acid a bad thing?

The mandatory addition of synthetic folic acid to our food supply back in the 1990s was in response to an increase in neural tube defects in newborns. Fortificaton of processed foods initially appeared to have a positive effect in reducing this serio

What is heme? What are Porphyria or Pyrrole disorders?

Heme is an important molecule consisting of an iron atom embedded in a structure of porphyrin: 4 pyrroles, which are smaller rings made from 4 carbon atoms and 1 nitrogen atom. Heme is a cofactor for many reactions in the body, as well as a part of t

I see really healthy foods can inhibit detox enzymes like SULT. Does this mean I should avoid eating them?

Absolutely not. The beneficial role of eating a diet rich in fruits and vegetables is very clear. The many benefits derived from fiber content, vitamins, minerals, antioxidants and other phytochemicals greatly outweigh any downside from slowing enzym

Are the listed inhibitors/promoters of gene expression inhibitory/promotional at physiological levels?

Research may show inhibition/promotion in mice at a given dose per body weight in mice, but scaled up to a human the equivalent dose would be unrealistic, eg: cups of a substance normally ingested by the teaspoon. It is not always possible to ascerta

I see a nutrient (herb, food) I should avoid due to one SNP, but elsewhere it is recommended that I consume that same nutrient to support a different SNP. This is confusing. What should I do?

Given that physiology and biochemistry are extremely complex and multidimensional, one has to realize that it is not possible to target one isolated gene without impacting a multitude of others at the same time. This is the reason the StrateGene team