Methyl B12 with L-Methylfolate Dr. Lynch Q&AUpdated 18 minutes ago
| Question | Answer |
| My son and I have the MTHFR mutation. Our B12 levels test normal, but I know that doesn't necessarily mean it is going where it needs to go. Two questions. 1. I have a lot of autoimmune issues (Hashimotos MCAS, Psoriatic Arthritis and CIDP) that cause inflammation. There are too many supplements for me to wean through to figure out what I really should be taking. Ideas where to start? 2. My son is also suspected to have MCAS due to high histamine levels. He has severe ADHD and anxiety as well. We suspect he may also be on the spectrum. He is not taking any supplements currrently, including Methylfolate. Ideas of what he should take to help with neuroinflammation? | You have a great statement about supplements - 'there are too many for me to wean through to figure out what I really should be taking.' The best place for you to start is baseline.
Both of you will do well with these suggestions. In terms of supplements, I have some foundational ones but I don't really want you taking any supplements until you work through the steps above. Many of the things you both are struggling with may improve a lot. Once you work through the list, then consider these supplements:
In health, |
| Hello Dr. Lynch- I just started reading your book and I'm so greatful I found your reel about stopping (pausing) all supplements! I was actually reading all of the Q&As to get as much information as possible as you suggested in the video. ;) I took B12/Folate by Metagenics for 15 years. I recently switched to your Multivitamin MF. I noticed a lot less anxiety/irritability in the morning after taking it and felt amazing for the first 2-3 weeks. However, I'm now starting to feel depressed, panicky, blood sugar dropping on the middle of the night and poor recovery after workouts. I wanted to switch over to your lozenge but wondering how to do this correctly. Do I take it until I feel "good" then stop. How do I know when I have to take that vs the Multivitamin MF. I have OCD so making these types of small decisions is difficult! HA. Thanks so much for your time!!!!!!! MTHFR C677T (+/-): reduced folate metabolism. COMT V158M (+/-) and VDR Taq (+/+): impaired estrogen and catecholamine clearance, heightened sensitivity to methyl donors. CBS C699T (+/-): potential sulfur sensitivity, excess ammonia, rapid transsulfuration pathway. MTRR A66G (+/+) and MTR A2756G (+/-): increased B12 demand, poor recycling. CYP1B1 and CYP3A4 variants (+/-): estrogen detox pathway sluggishness. SOD2 (+/+): impaired mitochondrial antioxidant defense, especially against estrogen metabolites. | Happy to hear you enjoyed Dirty Genes and found stopping supplements helpful. The key is this: Pulse Method Basically you want to take a supplement when needed, do not take it if you're feeling good and if you do take it when you're already feeling good, you're likely to experience side effects due to too much of that nutrient. Supplement is based on need. Working out and exercising is demanding so what I often recommend is taking 1 lozenge of Brain Nutrients prior to exercise along with a serving of Optimal Electrolyte. This combination supports a healthy workout and mood.* You'll also have different experiences based on the timing of your cycle. Prior to ovulation by a week or so, your mood may lift but then get to headaches and irritability followed by after ovulation experiencing more sadness and anxiousness with some anxiety. Watch how you feel during your cycle. If you feel good prior to ovulation and just at ovulation - but right after, your mood drops and anxiousness increases, that can be due to low serotonin levels. Consider supporting healthy serotonin by taking 1 capsule of Serotonin Nutrients after ovulation on days that you need and stop taking it when you feel you're happy with how you're feeling.* You may want to support healthy estrogen levels by taking DIM+I3C for a week or so prior to ovulation if you find yourself with increased irritability, breast tenderness and difficulty falling asleep.* I know this doesn't address the multivitamin but I think it's more cycle related than multivitamin related. :) If needing more support, reach out and let me know. Keep me posted how this supports you. In health, |
| Hello Dr. Lynch! I'm so grateful for the work that you do. I was taking B12/Folate for 15 years and recently switched to your MF Multivitamin. I noticed a lot less irritability in the mornings after I made the change. I got my period in September after I stopped breastfeeding last summer and had 5 regular periods with no PMS symptoms until I got COVID in January. I have a history of PMDD and that completely took over after having COVID. I started taking 100mg 5-HTP in April and it helped tremendously!!! I don't feel its effects any longer. I also need to point out that this cycle was different because we had a 9 hour time change due to travel and I also have a history of hypothyroidism (which I've kept in check with regular acupuncture) and my TSH skyrocketing from the altitude every time I get on a plane! (I've noticed this happen even with just a 1 hour time zone change in the past). I don't travel as much as I'd like to because of this. I'm now dealing with horrific anxiety/panic since day 3 of this cycle. I had wake-up's in the luteal phase every night between 3-5am! I no longer had these terrible symptoms after starting 5-HTP. I was still taking B-12/Folate every day at the time up until 5 weeks ago. I'm wondering what to do! Help! I don't know if I should increase 5-HTP to 200mg per day or go back to B12/Folate or order your lozenges. I'd really appreciate any insight you can offer. I'm on vacation right now and really struggling with 3 small children to take car of. Thank you so much! | In these situations, I'm thinking the estrogen may be elevated and contributing to your anxiety if it's around ovulation. During your luteal phase, estrogen levels drop, which means your serotonin levels drop - which may also lead to increased anxiety, constipation and waking up too early. Support healthy mood and sleep during your luteal phase with Serotonin Nutrients - 1 capsule before bed and perhaps another 1 capsule after your protein based breakfast in the morning - depending on how you are feeling.* In health, |
| Hi Dr. Lynch. What are your thoughts on transdermal estradiol cream for perimenopause symptoms? I have the 2 gene variation of MYHFR and lost a full term still born in 2003 due to blood clots in the placenta so I’m a little nervous about taking the cream that my doctor prescribed. Thank you | I'd look into the vaginal estrogen suppository vs just on the skin. This supports the vaginal tissue more locally vs full body. You're wise to be cautious. Too much estrogen is a problem - but so is too little. Few things:
In health, |
| This week I had my second consult with Chris Bramich regarding my MTHFR gene mutation. First consult was a year ago. Second consult this week. My recent lab work shows Homocysteine 10.9, B12 >1500, Folate >24.8. He reviewed all lab scores. One of the recommendations he gave was to alternate all methylated vitamin by taking them every other day. He commented that Dr Ben Lynch also makes this recommendation. QUESTION: Does that mean I should only take the Homocysteine Nutrients every other day? | Correct. Giving yourself a break from methylated nutrients is highly recommended. Given that your homocysteine is still a bit elevated - not much - yet your B12 and folate are, consider supporting with glutathione. Consider:
In health, |
| Hi, I’ve been taking this supplement for about 3 months. Just one lozenge. It’s not helping with energy. Should I be taking a different form of vitamin B? Please advise. Thank you | Thank you for reaching out. Low energy can be associated with many many things.
Consider:
Continue using the lozenge as needed - you may just need more or stay on it longer - or need the additional support above to get the full effects. In health, |
| Hello, Thank you so much for your response. Based on your response below, I have been taking your glutathione plus on and off for two years. I ordered it again on 5 April and have been taking it after being off for about two or three months. Should i switch to the lozenge? How long do you suggest i stop taking the vitamin b complex? When I start the vitamin b again which one should I take, do you have one that will work for me? Based on some labs and symptoms my doctor seems to think I might be going through B6 toxicity and suggest I stay off of it for a while. My homocysteine test was fasted. However, the homocysteine nutrients you suggested have B6 which I’m trying to avoid is there something else I can take? Thanks again for your response, I appreciate it so very much. I feel lost overwhelmed and scared. These doctors are clueless and I don’t know what to do. Thanks, Ayleen Nichols On Monday, May 19, 2025 at 07:40:56 PM EDT, Seeking Health <[email protected]> wrote: Hi Ayleen, Seeking Health answered your question about Methyl B12 with L-Methylfolate. Q: Hello, I wanted to ask questions on the MTHFR mutation. I got a blood test that showed I am positive for it. It says I am positive for one copy of the C677T and one copy of the A1298C variant. My HOMOCYSTEINE level is 14.9. My vitamin b12 is 607. my folate is 498. My vitamin b6 plasma is super high at 47.5 and normal levels are up to 21.7 but I am wondering if that is because I am taking a vitamin b complex that has 35 mg of it and its over the daily value. Everything is normal except for the vitamin b6 plasma. I am not sure where to go from here and I do not really understand what being positive for this gene means and was hoping you could tell me what I should be taking. thanks, Seeking Health's Answer: Hi Ayleen - Well formed question - thank you. The homocysteine at 14.9 umol/L is actually high. According to research articles, you want your homocysteine levels between 6 umol/L to 8 umol/L. Consider: Glutathione Plus Lozenge: 1/2 a lozenge upon waking to support healthy glutathione levels which are needed to help recycle homocysteine.* Homocysteine Nutrients: take 1 capsule after a protein based breakfast in the morning to support a healthy homocysteine level.* Stop the B vitamin complex for now - and especially stop it completely if is using Folic acid - you do not want that. It's a very inferior folate and with MTHFR, you need more active folates. Fish Oil: 1 capsule after dinner to support healthy cell membranes.* watch your intake of protein - don't eat too much - aim for 1 gram of protein per 2 lbs of body weight if exercising, go for it - just don't go excessively hard because intense exercise raises homocysteine be sure to do your homocysteine test fasted and you can retest in 1 month after the above recommendations have been followed. In health, | A high B6 can be due to the supplement yes. You may pause B6 for a bit and see how you do. I really enjoy the Glutathione Plus Lozenge - it's one I use a lot in our home. I never use the capsules or liposomal form. I like using 1/2 a lozenge of glutathione upon waking and also take it on the plane with me. To support healthy homocysteine levels, consider:
In health, |
| Hi Dr. Lynch, I have the compound heterozygous MTHFR mutations and up until the last year and a half I don't think it has been giving me any issues. I have been experiencing swelling in my jaw and neck, intense brain fog, itchiness, fatigue, headaches, numbness and tingling in my extremities, among a myriad of other things. I did move back to CA two years ago and I am sure some environmental allergies may also be coming into play. I recently got a micronutrient b panel done and my b2 and b12 were both low and just barely within range of being normal, b6 was high at 30, folate was 8, and homocysteine was 6. For context, I also have POTs and have had extensive testing done for autoimmune diseases and allergy testing done. No autoimmune disorders and just a few environmental allergens came back "positive". Under the recommendation from my doctor I did a liver detox that used NAC, glutathione, milk thistle, and a few other "detox" supplements but it seemed to make symptoms even worse. I also tried taking a supplement called D-Hist and that also made the itchiness and swelling in my neck worse. I am thinking of taking Seeking Healths riboflavin, methylated folate and B12, and using the optimal electrolytes. I wondered if you think this may be a good start? Thank you for taking the time to read and respond to our comments. | Good question and detail. A few things to consider:
In health, |
| does this product increase iron levels ? I have hemachromatosis, and watch my iron levels closely. | It does not increase iron levels. I'm glad you're being diligent! :) I'm sure your doctor already told you but if not, donating your blood can be quite helpful in lowering iron levels. In health, |
| Hello, I wanted to ask questions on the MTHFR mutation. I got a blood test that showed I am positive for it. It says I am positive for one copy of the C677T and one copy of the A1298C variant. My HOMOCYSTEINE level is 14.9. My vitamin b12 is 607. my folate is 498. My vitamin b6 plasma is super high at 47.5 and normal levels are up to 21.7 but I am wondering if that is because I am taking a vitamin b complex that has 35 mg of it and its over the daily value. Everything is normal except for the vitamin b6 plasma. I am not sure where to go from here and I do not really understand what being positive for this gene means and was hoping you could tell me what I should be taking. thanks, | Well formed question - thank you. The homocysteine at 14.9 umol/L is actually high. According to research articles, you want your homocysteine levels between 6 umol/L to 8 umol/L. Consider:
In health, |
| Recently diagnosed with Hashimoto disease, not taking any medication for this currently trying to do lifestyle change. Alkaline Phosphatase were 42 lower side, Methylmalonic Acid, Serum 84 nmol/L and MCV 97fl- is this is the best form of B12 to take? If so, would I take the recommended dose? Thank you! | If methylmalonic acid is elevated, that's a sign of an adenosylcobalamin deficiency. I'd look into:
This combination supports healthy MMA and MCV levels.* For a low alkaline phosphatase, the most common contributors to this are:
In health, |
| I have the MTHFR gene and took your prenatal for support with no issues. I stared taking this Methyl B12 a few weeks ago and have experienced a sunburn like affect about 10 minutes after taking it that goes away within 45 minutes. This does not happen everyday, but at least a few days a week. Is this an expected side affect? Is there something else you can recommend for MTHFR gene support? Thank you, Lauren | What you're experiencing is ok as long as it's not contributing to anxiety or headaches. It may be due to the increased blood flow due to the increased nitric oxide levels that are supported by folate and B12. If you're feeling good afterwards, then it's good to keep using. If you're not, then consider using less - say 1/2 a lozenge - and less often - perhaps every other day or so. You may also want to swallow the lozenge vs letting it dissolve. This way the nutrients hit your blood a bit more slowly. Additionally, taking it after eating some food could be useful. In health, |
| Hi there, I am currently giving my son folinic acid and his hyperactive behaviour has increased. A friend recommended that I give him Methyl b12 to combat this. Is this true? | Any folate may increase hyperactive behavior. Methylcobalamin may increase it further. What often happens is doctors and parents give a necessary nutrient and it works really well in the beginning. Then, after time, side effects like you're experiencing occur. That's likely because the deficiency that was there is no longer there - and now he's experiencing excess folate which is contributing to side effects. I recommend pausing the folinic acid for now and then consider using 1/2 the amount you were using on an as-needed basis. Read this article: Your son may do well with the Kids Optimal Focus Chewable - and start low at say 1/4 to 1/2 a chewable - but do not introduce this until you have adjusted the folinic acid. In health, |
| I started using Methyl B12 for my homocysteine that was 12 . After a couple of months it went down to 6. Great stuff. Was wondering if you think I have the MTHFR? Can you recommend a good company that tests genetic SNP’s? | Awesome :) Don't go any lower than 6 umol/L. We want to have homocysteine between 6 - 8 umol/L Homocysteine can increase for many reasons - not just SNPs. If you're looking for a great testing company, I do recommend SelfDecode or Sequencing.com In health, |
| Hello! My daughter is scheduled to go under general anesthesia on 4/11 for dental work. The first stage is nitrous through a mask. She has MTHFR and I know nitrous is contraindicated with MTHFR but unfortunately I don't have another option. What would you recommend to support her body through this. I know while pregnant with my second I discovered with your prenatals I could not tolerate the methyl B vitamins and had to switch to the non methylated version. Scared my daughter woulf have the same reaction and I definitely don't want her heart rate elevated while going under. So, I'm not sure if just B12 is the best or B12 and folate, what dosage, OR just the chewable multivitamin (methyl or non methyl)? Thanks so much! Mandy | Please read this article about nitrous oxide: There are other potential options for nitrous oxide in the article - one is just not using it and using other things to calm down. If you are sensitive to methylated nutrients, that's no problem. Your daughter may consider using these before - and after the dentist:
This should support her very well. In health, |
| I purchased this product to help with sulfite allergies, but I had a reaction when I took it for the first time following the recommendation to take half a lozenge. I have allergies to both sulfites and sulfur-containing foods. I currently take molybdenum and calcium D-Glucarate, which has been very helpful. I've had similar reaction to NAC as well (swelling). Is there anything you would recommend? | Using this for sulfites is not going to help. The Molybdenum and Calcium D Glucarate are great choices and I see they are helping which is great. I'd increase the dosage of these two supplements and limit sulfur containing foods and drinks. You may also find that adding Digestive Enzymes - 1-2 capsules with each meal - be supportive of healthy digestion.* In health, |
| Is this save to use for 7 years old non verbal autism child to improve speech & cognitive? | I would not pick this one. Instead, consider:
This is a great start. Keep me posted. In health, |
| I homozygous MTHFR. I am struggling with stomach issue. Mainly pain in upper abdomen after eating and heartburn. I am slush struggling with high blood pressure. I’ve tried to take methylated B vitamins before and I have anxiety and they hurt my stomach. My main goal is to get my digestive stuff in order and lower my blood pressure! I am currently taking B2 since I’m homozygous. Is there anything you can do to help with this? | I would not use methyl B12 or methylfolate right now. I'd look into what foods you may be reacting to. High histamine foods or drinks along with high fatty foods or just foods you are sensitive to may be worsening your symptoms. Consider working with your doctor to test for common food intolerances. I like this lab test: This Gallbladder Guide could be supportive for you: Consider:
This is a comprehensive, non stimulating approach to supporting a healthy gut and healthy blood pressure. In health, |
| Hi Dr. Lynch, My traditional PCP ran some lab work as I have been experiencing numbness and tingling in my legs without any risk factors. My lab results came back with my Folic Acid level at 10 and my B12 at 412. I've tried taking methyl folate and methylcarbylamine but it made me extremely anxious. I'm not sure how to support my MTHR gene as I'm homozygous 677T/T. Thank you for your help! | There are a number of reasons why numbness and tingling may occur. Make sure they evaluate your spine and muscles as well. Consider:
The Brain Nutrients contains B12 and folate along with additional antioxidants and thiamine which are needed to support healthy nerves. This combination should provide benefits within a week or two. In health, |
| Hello Dr Lynch, I got terribly high blood pressure probably because of high homocysteine. My doctor doesnt do a homocysteine test, but I have all the symptoms including family history. I wasnt able to reduce it with tmg and b vits only had to add, following your advice on Youtube, S-acetyl Glutathione, it dropped so i cycled off glutathione (kept taking b vitamins) and now it went up again. Do you think having S acetyl Glutathione as a permanent supplement would make sense? | I like how you're taking action knowing yourself and your family regardless of the fact that your doctor won't run a test. Well done. I like what you're doing here overall. Keep it up. Consider some more supportive long term foundational support that supports full body vs just homocysteine - this way you'll support healthy homocysteine levels along with other key functions like healthy mood, healthy sleep and healthy detoxification and memory.*
This is a more comprehensive plan for all systems go vs just circulatory. In health, |
| Thank you so much! I will purchase the hydroxy b12 and folinic acid lozenge for my mcv level. About the cortisol, I want to double check about adrenal cortex. My cortisol reading was 8.3 at 11:15am. I had been taking stress nutrients for weeks prior to this so just confirming that adrenal is the way to go or maybe just stop stress nutrients and see if it naturally raises again? I don’t want to freak my system out any more than it has been! I usually feel fine come afternoon- no anxiety- but I do feel as though some evenings I am ready to clean the house… sometimes… and it’s harder to fall asleep. (Your Lithium orotate has helped with this but is it also lowering cortisol?). My backwards energy does make me think my cortisol is confused or something. Last, after taking the d3/k2 you suggested, my vitamin d was too high around 107. Ha! My b6 was also elevated at 39.8 (the upper limit is 21.7). Is it still ok to take the prenatal with these readings or take a break? I know some say a level of 80-100 for vitamin d is optimal but I think I’m overboard :). Was going to stop the d3/k2 for a bit (my naturopath recommended 6 weeks) and then maybe take it every other day or somehow take 2000ius less. Thank you again for helping me! You have helped so much! | Lithium does not lower cortisol - it supports healthy dopamine and norepi levels from an excitatory state to a healthy state. I like your idea of stopping the Stress Nutrients and seeing if that's sufficient. The issue is if you're not sleeping through the night, you may need the Adrenal Cortex on SOME MORNINGS - maybe once or twice a week - not daily. Supplementation requires awareness. How are you feeling prior and after -then analyze the findings and adjust - each day. Some days you will need Stress Nutrients and other days you'll need Adrenal Cortex - and it may not be even days that you may need them - it may be a couple days out of a month or a few days a week - all varies depending on what's going on in your life. Backwards energy does tell me it's confused yes - and Phosphatidyl Serine before bed could be helpful. Vitamin D3 - do pause that for now. I'm not sure what the value should be as there are genetic variations here and the labs measure inactive 25 OH not the active 1,25 OH so it's hard to say. B6 I wouldn't worry about that. Again - supplement based on how you feel. If you wake up and feel good after having some electrolytes, maybe that's all you need. Other days you may need the prenatal with a protein based breakfast. Analyze - and you're doing a great job of it looks like! Best |
| Hi! I have recently had some bloodwork run and my mcv was elevated (which I feel it always runs on the higher end but this time over normal). My homocysteine was 5.8. I was taking homocysteine nutrients but stopped it 6 weeks ago. Does a high mcv indicate a need for b12/folate and would this lozenge be helpful? I’m compound hetero for MTHFR but that may or may not matter. I also was taking optimal electrolyte, fish oil, and 1 capsule of prenatal essentials MF. In addition, I was taking stress nutrients due to anxiety but am switching to adrenal cortex bc cortisol came in low and I’m waking around 3/4 at night. I feel like my blood sugar is wonky too which causes the anxiety but wondering if the adrenal cortex might help in that regard too? Thank you for taking the time to respond to this! | Sounds like you're on track here. Consider:
In health, |
| Looking for you easiest on the stomach form of mthfr support. Struggle with nausea on most supplements. Would like a multivitamin or b complex but understand if it just needs to be something simpler like this methyl b12 and methylfolate product. | I prefer knowing what symptoms you're looking to support vs just saying you need MTHFR support. I say this because just because you have a MTHFR variant does NOT mean you need to supplement. Depends.
If you say yes to any of these, then the Methyl B12 with L Methylfolate lozenges would be a great fit - and start with 1/2 a lozenge. They are very easy on the stomach. I would consider starting with a more foundational approach though vs this targeted supplement. Consider:
Our supplements are usually very well tolerated as we use chelated minerals, not tablets and high quality ingredients. I'd start with the four supplements above and I suspect you'll feel way better ;) in 24 hours. In health, |
| Thank for writing me back, I know that everyone has the genes , mine came back with a mthrf and comt issue. Looking for support with mood, energy and stress but can’t afford a lot of supplements. If I could only pick one what would you suggest. Trying to handle most of it with food and lifestyle. Also I have read your book, thanks for making it easy to read for people that don’t have a science brain. 😊 | I'd start with either Optimal Electrolyte or Glutathione Plus Lozenge. One or both of these is a key starting point. You'd have 1 serving upon waking and another midday. Make sure you're eating protein with each meal. This is key. Do not start your day with caffeine, sugar and carbs. That will wreck your day. In health, |
| If you have the mthfr and comt gene but can only afford one product, what would you suggest? I know food and lifestyle are first and for most. | We all have the MTHFR and COMT gene :) What are you looking to support most - what is your primary goal? What are you struggling with? Best, |
| My daughter (5) has enlarged tonsils that cause her to snore at night. Her CBC also showed low red blood cell count and low hematocrit. She is often tired and irritable. I (her mother) have a history of low b12 and folate levels. Could this methyl b12 and glutathione help with her large tonsils and mood? What would be the dose for a 5 year old? | Great questions and good thoughts. A lot RBC count and low hematocrit can be iron or folate deficiency or both. A few things here:
That should help a lot. Keep me posted. In health, |
| Hi Doctor Ben! I'm getting ready to start your Methyl B12 w/ L-Methylfolate. After working up to 1 Lozenge per day, is it ok to take that longterm along with a B Complex? (I have Ortho Molecular's Methyl B Complex on hand,...). I have 1 copy of the MTHFR SNP and am working with gut support to heal histamine intolerance. Your wisdom and supplemants have been SO helpful!! Thanks so much, Carole | You're welcome ;) Happy to help! I caution you to use so many B vitamins if struggling with histamine intolerance. Here's something to consider:
Start here and keep me posted. Too many people over do B vitamins and struggle because of it. I want to see you thriving ;) In health, |
| Hi! I am writing to see if I can help my father in law. He had bypass surgery last Wednesday. He is currently in afib now (heart rate running around 122 so its hard for him to walk as he’s supposed to) and his rbc, hematocrit, and hemoglobin are all low. While I know you cannot give medical advice because you don’t know his health history or other medications, I'm just wondering if there are things that might help support his body in a healthy direction. He is drinking 1 serving of optimal electrolytes per day. I was wondering if this lozenge would help since he was under anesthesia for so long and also bc it seems he must have low iron (hopefully checking that today). If you are not comfortable suggesting anything I understand, but thought I would reach out! Thank you! | I'm helping out by answering some of the questions we are receiving. I'm sorry to hear about your father-in-law :(. My father went through the same a few years ago. Just remember, it's common for blood markers to be very 'out' post-surgery. Often they look different a few weeks later. Surgery is a huge stress on the body. Here are some suggestions:
You may also consider more long-term:
Make sure to discuss any supplement changes with his healthcare provider. All the best :) |
| Dr. Lynch, thank you for the informative, detailed MTHFR/Methylation webinar on Wednesday. I have a question for you on optimizing energy/mood. Despite cleaning up my genes, I am continually dragging. Per Oura ring data (which I leave in airplane mode except for a 15-minute sync each morning) I'm logging optimal sleep, readiness, and activity scores, so I feel like I should rise each morning feeling less wrecked. My house is hard wired, so I have less exposure to nnEMF that most people I know. I am actively working to reverse insulin resistance (single-ingredient/whole foods, very low carb, moderate protein, 1-2 meals a day, fast for at least 16 hrs), get regular exposure to natural light, some red light therapy when I remember, and I use a Sperti D lamp from Oct-May. I know we aren’t supposed to “treat” our SNPs, but it can be challenging to identify which symptom I need to resolve/pulse, given an overall feeling of malaise. I’d love to know what you might recommend to boost mood and energy, which may motivate me out of my rut. If this helps inform your input, I currently take your glutathione lozenge and D3/K2 drops every morning. I cycle Homocysteine Nutrients with Multivitamin One each week. And your histamine supplements are a part of my daily life (Digest, Nutrients, and ProBiota HistaminX). After watching the MTHFR webinar, I ordered Optimal Electrolytes and Methyl B12 with L-Methylfolate, as my homocysteine levels are traditionally 12+, to be tested again in 2 weeks. Per the Strategene report, my notable SNPs are: NAT2 (Haplotype intermediate. TH (fast), DRD2 (slow/fast/slow), COMT (Haplotype intermediate), SLC18A1 (slow). MTNR1B (slow), CYP1A2 (contextual), UGT1A (Haplotype contextual). MTHFR (very slow 30%). MTRR & PEMT (slow), PON1 (contextual). GSTA1 (very slow), GST01(fast), NOX/CYBA(fast). GCH1 (slow Haplotype slow) | You're welcome ;) Glad you enjoyed the webinar. I suspect you're not eating enough. Not eating enough can leave you dragging. Consider:
This should help a lot. Keep me posted. In health, |
| My husband was directed to take 15mg of methylfolate with his SSRI because of his MTFR gene. I am noticing that the dosage of methylfolate is alot lower in the Seeking Health supplements. Is there a reason? I know the sublingual version would be better absorbed, and can not find one that is anywhere close to 15 mg anywhere. Would taking this be enough? | Wow! 15mg of methylfolate is a lot to be honest, especially in one go. I would be reluctant to prescribe this much without trying it first. I would also be really surprised if he needed that much. Most folate supplements only contain 500mcg, maximum 1mg of methylfolate. Methyl B12 with L-Methylfolate contains 800mcg which is a good dose. Start with 1 lozenge first. It's likely to be enough for your husband. You can always build it up with L-Methylfolate if needed. If he feels more anxious on L-Methylfolate then consider switching to Folinic Acid instead. I would also consider:
This helps to support MTHFR and serotonin production.* Regards, |
| Hi! I have a hard time understanding some things regarding MTHFR, but I am learning and listening to every podcast I can find. We have not done genetic testing before, but I feel pretty certain that my husband and I both have it and our 4 kids who suffer from a bunch of issues, like EOE, food allergies, mold illness, CIRS, chronic lyme, gluten ataxia, anxiety and much more, have it from both of us, MTHFR homozygous. We will do the testing as soon as we can afford, but until then I hope to support us all the best I can. Years ago I started using Orthomolecular Methyl B Complex, when our functional medicine doctor told me she suspected I was MTHFR and I loved it. After listening to some of your interviews, I ordered an optimized folate and a methylcobalamin, but then I heard you say to use them everyday, but try to listen to your body. I am trying, but it is hard. I want to also support the kids, my 14 and 12 year olds could definitely use the support in school for focus and endurance. I am tired all the time, the last think I want to do is over methylate and be more tired. I don't want to unknowingly make myself worse or the kids! I heard maybe hydroxocobalamin or adenosylcobalamin are the way to go to that you don't overstimulate your methyl or whatever. Are these good for the MTHFR people? I think you have one that says no methyl, is that good? Also interested in the PPQ, do I need to take that with a separate CoQ10? And is it ok to try TMG, it sounds like it helps! Thank you so much! | You missed an excellent webinar tonight specifically addressing MTHFR :) It's recorded and available for Members in our Education portal. Become a member here: I highly recommend you watch it - First things first:
To help you get started, consider:
The Glutathione Plus has some PQQ in it. Start with the foundations above. Then check in a couple weeks and let's refine it. Definitely get the Membership so you can start really learning in depth and not be guessing. In health, |
| How does one know if Methyl B12 with L-Methylfolate is more appropriate for them vs. Hydroxycobalamin with folinic acid without genetic testing? Does high homocysteine in bloodwork point to which one is better? | Genetic testing does not necessarily provide the answer to which form of B12 and folate is best for you. Neither does high homocysteine. The best way to determine is to monitor how the different forms make you feel. Some individuals do great with methylated forms of B12 and folate. Others may find it too stimulating which can make them feel irritable. If this is the case then hydroxycobalamin and folinic acid may be better choices. Start with 1/2 a lozenge first of Methyl B12 with L-Methylfolate and see how you go before taking a full lozenge. It's good to also know that hydroxycobalamin can convert to methylcobalamin and folinic acid to L-methylfolate. Hope this helps :) Regards, |
| What is the ratio of Methyl and Adenysol in this product? | It's proprietary but there is more methyl than adeno. In health, |
| Love seeking health, looking for a little help, I had few tests ran and I have mthfr gene, and they said that my methylation pathway is also blocked, I have huge histamine problems, skin, insomnia ,headaches, very painful skin ,this has been going on for over 8 months, I have suspected mcas, my question is, would I be better with a multivitamin or a form of methylfolate, to support methylation ,as probably why cant get histamine down I also have a dao enzyme tested which come back, 3.6 so super low, any advice is much appreciated many thanks in advance | If your DAO enzyme came back low, I'd add in:
This is in addition to the other recommendations. Keep me posted. In health, |
| Advice Hi there I have the mthfr gene, and I'm unsure if I should be taking this methyl folate or something other, I have mast cell issues after a virus along with terrible insomnia, someone did say he had great effect with this product can someone offer advice please? many thanks | It's hard to say who is the best candidate for this supplement. It's more a trial to know for sure. It's also useful at times vs daily. I had the virus and after the virus, I found that I needed a lot of this supplement and it really helped me. Now I use it once a week and right after the virus, I used about 7 of them a day spread out throughout the day. Poor methylation, due to low methylfolate and low methylcobalamin, can lead to mast cell issues. This supplement supports healthy methylation.* Consider:
In health, |
| Being MTHFR 1298C Heterozygous I started taking this product a week ago and my when my blood test came back today my Folate serum level was above 24.000 ng/ml and my Homocysteine was high at 18.8. Should I being looking at supplementing with something else and/or adding to this product. Thanks | Homocysteine high is the most important point here along with the high folate. This tells me that your folate is stuck and is not helping recycle the homocysteine. Consider:
Check back in a month with new lab findings. Important: When taking folate supplements, you need to watch out for getting irritable or headaches. If you're getting these, then you need to reduce how much you are taking. In health, |
| Hi, I have had vertigo/dizziness for 3.5 years. I’ve been told I have a vestibular disorder and most likely the MTHFR gene. I cannot get the dizziness to go away! I’ve been told that taking B12 might help as my bloodwork shows it being on the lower end of normal. Would you recommend this supplement and if not, what would you recommend to help with 24/7 dizziness and frequent vertigo? | Methyl B12 with L-Methylfolate will help improve your B12 levels, so definitely recommend it if your B12 levels are not optimal. Vestibular vertigo has a few different causes such as:
B12 deficiency can result in reduced blood flow to and from the brain which can make vertigo worse.* You may also try something like Histamine Nutrients 1 capsule twice a day. Let us know how you go :). Regards, |
| Hi there, my son is almost 2 and is having trouble going to sleep at night. I read it could be due to low b vitamin levels. He was also born with a tongue tie, sacral dimple, and stork bite so I’m assuming he has some sort of MTHFR but we have not gotten him tested. Would this be a good supplement for him to take? If so what would the dosing be like? Thank you for your help. | There are many factors for sleep issues. Consider:
In health, |
| Hi there. I have the MTHFR gene turned red in my report I received. The rs1801131 (A1298C) was red. The "SOD2" (rs4880 (VAL16ALA)), "FUT2", and "FAAH", "DRD2" (rs6277 (C957T)) is also red. I have had hashimotos and have healed it from detoxing and parasite cleansing. I have an ok amount of energy but I am having a hard time losing weight. I also get headaches sometimes and not quite migraines but I can feel my nervous system and gut almost go there. Wondering what you would recommend to take for maintenance? | I'd start with some fundamentals before we hit specifics. Consider:
Keep me posted. In health, |
| How can I use this to improve my sleep? And do you have any other recommandations? | You'd take this in the morning before your breakfast to support healthy onset of sleep. Sleep is multifactorial. Supporting healthy onset of sleep:
To support healthy duration and extended sleep:
General health support which supports healthy sleep:
These are general recommendations and use them as needed and only as needed. I listed a variety of them as every one is slightly different and at different times one needs different support. I'm not saying take all of these at once - far from - just giving options. In health, |
| Hi, What blood test should i do b9 or folic acid? To know what my range is? Thank you | Folate blood testing is tricky. Serum folate is a common one to order. Know that serum folate includes all forms of folate including folic acid. Looking at the CBC's MCV and MCH is another way to get a gauge on red blood cell health which requires healthy levels of B12 and folate. High MCV and High MCH is associated with low folate and/or low B12. Know that folic acid can mask (hide) a vitamin B12 deficiency so be mindful of that. I do not ever recommend anyone to take folic acid. Use folinic acid or methylfolate or the combination of them both instead. In health, |
| I am taking Methyl B12 but have a heavy feeling like my B12 is low. My labs show my B12 is in the high range. Which of your B12 should I take if I have MTHFR C677T and A1298C (both heterozygous) and COMT V158M and H62H (both homozygous)? Thanks in advance! | Taking vitamin B12 without methylfolate may be ineffective as it may lead to methyl trapping. Methyl trapping will lead to increased levels of homocysteine and methylation issues as a result. Methyl trapping occurs if:
That list is not exhaustive but it's pretty thorough. A combination of MTHFR compound heterozygous with a slow COMT means one has to be mindful of how much magnesium they have on board, how much homocysteine and be mindful how they are feeling when they are supplementing with methyl donors. Consider:
This combination is very supportive. Take these supplements on an as-needed basis. If you wake up feeling great, just take a bit of the Glutathione and possibly 1/2 scoop of the Optimal Electrolyte and skip the Methyl B12 and Methylfolate. In health, |
| Can you take this every day with Brain Nutrients? | You can but do you need to is the question. If you need it, absolutely go for it. What's important is to first realize how you are feeling, then take one of the supplements, see how you feel from taking that and evaluating if you need additional support or not. For me, I usually take 1/2 to 1 lozenge of Brain Nutrients in the morning upon waking - first thing in the morning. This makes me feel pretty good for an hour or so then I make a glass of Optimal Electrolyte and sip that at my desk for about an hour or so. If I feel my brain underperform, then I could either take a Methyl B12 with Methylfolate Lozenge (1/2) or another 1/2 to 1 lozenge of Brain Nutrients. I usually use Brain Nutrients and I have it on my desk along with Optimal Focus and Optimal Electrolyte. What you want to feel is good: good energy, good mood, good cognitive abilities. If you feel you need more support, then add it. If you feel good, then skip it. In health, |
| Regarding sublingual B12 (all versions you carry), I have recently been told that the vitamin B12 molecule is too large to be absorbed sublingually. Can you tell me your understanding? Thank you! Kim | Research shows that sublingual delivery of many nutrients is effective. Is sublingual MORE effective? That's to be debated as some research says yes and others say it's as effective as the oral route or a shot in the arm. We call these lozenges as they deliver the B12 in your mouth and then you swallow. The great thing about our lozenges:
In health, |
| Hi! My husband has severe obstructive sleep apnea caused by his underbite and high vaulted pallet that prevents his tongue from resting in the proper position. I would not be surprised if he had an MTHFR mutation but if he doesn't, his genes are certainly acting dirty. He has chronic migraines, weight gain, foggy brain, ADHD-like symptoms, and never feels well-rested. He does not tolerate his c-pap machine well so the only alternative is jaw surgery and a pallet expansion to fix the underbite and allow his tongue to rest in the proper position so that it stops falling over his airway at night. Until then, which supplements which you recommend to alleviate the sleep apnea symptoms, particularly the migraines? We eat a pretty nutrient dense diet of high quality meats, dairy, eggs, and organic vegetables but it doesn't seem to be enough to overcome just how depleted he is. Thanks so much for your help and insight! | If the migraines are caused by low oxygen, then we need to support healthy oxygen levels and healthy oxidative stress levels. Some things to consider:
I'd start here. He may also do well with adding in 2 capsules of Optimal Man with a protein based breakfast but let's start with the above first. ProBiota HistaminX after dinner along with Fish Oil could also be useful as a foundation. In health, |
| My 4 year daughter was diagnosed with MTHFR. I She is struggling with extreme nail biting (anxiety) and has a really hard time regulating herself when she gets upset. I haven't wanted to go the supplement route but I feel like i may be doing her a disservice. What dosage amount would you suggest with this product for her? Thanks so much! | I'd consider a couple options. Nail biting, called onychophagia, is associated with low serotonin levels. Consider:
Give one or the other first - do not give both at once as it will be too much. I also recommend giving her 1/2 scoop of Optimal Electrolyte mixed in a glass of filtered water. In health, |
| Is the adeno b12 suitable for an 8 year old? My son’s dr recommended he take b12. What dose is correct for kids? Can he do half the amount that’s recommended for adults? | For a child that is growing, I'd instead use Hydroxo B12 with Folinic Acid Lozenges and give him 1/4 a lozenge. OR Consider the Kids Multivitamin Chewable MF as it supports your son's B12, folate and other key nutrients as well. You would not do both. If your son has very low vitamin B12, then I'd consider 1/2 a lozenge of Methyl B12 1000 and give him 1 lozenge after breakfast in addition to 1/2 to 1 chewable of Kids Multivitamin Chewable MF. In health, |
| Hi there my mam was diagnosed with cancer and needs chemo and radiotherapy,she was reccomended to start taking folate acid ,can you please reccomend best one many thanks | My best to your mother. Often times oncologists recommend Folic Acid for their patients taking Methotrexate or other folate blocking medications. Folic acid is the wrong form of folate to use. The folate that should be used is Folinic Acid. If she starts experiencing mouth sores or painful stomach, consider Gut Nutrients as it supports a healthy mucous lining. She would mix a serving of Gut Nutrients in about 4 oz of filtered water. She would sip, hold, swish, hold and then swallow. Repeat. The relief is pretty fast and very important as radiation is known to cause mouth sores and gut sores. She would not use the Gut Nutrients if she is not experiencing these - OR she can take 1 serving before getting the chemo and radiation. She can also just use L-Glutamine Powder as I see you in the UK. That is likely the better option to use. Do that instead actually. It's not recommended to take antioxidants (as found in Gut Nutrients) during chemo or radiation. In health, |
| I have a MTHFR, adrenal fatigue, non alcohol fatty liver, inflammation, and other issues. Which supplements would you recommend I take? Thank you! | I recommend talking with one of our health professionals in our referral network. There are many lifestyle things that should be evaluated prior to supplementation. Reading my book, Dirty Genes, is also a great place to start. For a foundation and starter pack, I do recommend:
Make sure you start your day with protein - not coffee or sugar. Eggs, meat, whey or collagen protein smoothie. These three are a great foundational start for you. In health, |
| Dr. Lynch, Could you help me with trying to figure out what to do about high homocysteine (for the past 20 years)? Currently it runs between 13 and 17 and it is currently 17. I clearly have methylation issues >> I am 66, female, also have Hypothyroidism, Depression, and Histamine intolerance. I had 3 miscarriages after 1 normal birth. How could I be taking the following for many years everyday and not see a change in my Homocysteine level? L-methyl folate - 3500 mcg, DFE, 2100 mcg 5 MTHF; TMG Betaine - 4300 mg; Methyl B complex, N-AC- 2000mg, Liposomal Glutathione, Taurine, 3000mg. Not a big meat eater and very poor compliance with leafy greens- but trying. What am I missing? (You are one of the best- trying to help people with your knowledge and expertise while other doctors? - not so much). Thank you! | That's a great question. Do you know your genetics? I suspect you have some genes which are very dirty and it would be nice to know which ones they are. I'm curious if you have tried a 24 hour filtered water fast only and seeing if your homocysteine levels normalize. That is something I would do. I'd also consider adding in Creatine and Phosphatidylcholine. I am not sure which companies you are buying these from and that may be an issue- or maybe not. Consider stopping all of those for now and switching to Seeking Health's to see if the quality makes a difference - and the synergy of ingredients. I'd consider starting your morning with Brain Nutrients. Have it right on your bed stand and take 1 full lozenge immediately upon waking up in the morning. This is full of potent antioxidants along with some additional folate and B12, ATP and thiamine. I'd consider Homocysteine Nutrients and take 2 capsules with breakfast. Then, sip a glass of Optimal Electrolyte - or put 2 scoops in a liter water bottle with filtered water. Sip this over an hour or more. Before bed, I'd take 2 capsules of Optimal PC. I like chewing the capsules but everyone is different. You can swallow them but it's fun and the phosphatidylcholine tastes good and salty. Add in sauna. Detoxify. Here's how to sauna: Make sure you are fasting before you measure your homocysteine levels and do them in the morning - and at the same time. I suspect the histamine intolerance may be partially contributing here as histamine breakdown can increase homocysteine - depending on how significant it is. After dinner, take a capsule of ProBiota HistaminX. Before bed, take 2 capsules of Histamine Nutrients. Follow up in a month or so after implementing this and you get your new homocysteine levels back. Make sure you are not over exercising as well as exercise increases homocysteine. Go for walks and hikes - but no high intensity exercise. In health, |
| I used to take L-Methylfolate Lozenges from you guys, but i can't find that product online. Is it only available now to take with B12? I have tested as deficient and low in Folate. Will it be ok for me to take this with the Methyl B12 included? Last time i checked my B12 levels were just adequate but im not 100% sure. All i know is that i need to start taking Folate ASAP, as i tested low and i have symptoms of dizziness and focusing my eyes so im concerned its the low folate causing this. | I highly recommend you consider Brain Nutrients in addition to Optimal Man. Here's why:
Too much folate and B12 can increase irritability and anxiousness and we don't want that. I'd also drink a serving or two of Optimal Electrolyte. SIP it in your water bottle over time - do not chug it. It works best when sipped over time. Use filtered water always. If you're working on a computer all day like I am, consider getting blue light blocking glasses. I'm wearing prescription blue blockers right now and have been using them for years. Very handy and healthy for your eyes. I get mine at BonCharge here - https://boncharge.com/?rfsn=3416137.6ced97 - use code DRBENLYNCH to save 15% (I earn a commission). These recommendations should help you a lot. In health, |
| I'm looking for a complete ingredients list. Some of your products have it as a label picture and others a link that shows the label. I am not seeing either for this (and a few other) SH products. What is the full list of ingredients? | Thank you. We just updated the product page and some are missing. I notified the team and we will get this remedied for all products by Friday. Best, |
| I am doing very well with Methylated B12 but can't tolerate Methylfolate. I'm confused! Why can I tolerate one but not the other? The practitioner said I may be over methylating and would do better to take both B12 and folate non methylated. Could I continue with the B12 and address folate needs via food and/or non methyl folate supplement? I've had a test which says I have one copy of C6777T and up to to 40% reduction in gene function (there were many mutations in the test). | It may be because you don't need additional folate. Just because you have the MTHFR variation does not necessitate you to take methylfolate. You may be obtaining sufficient folate from your diet and not enough B12. If you feel fine, your lab tests are fine, then you are fine - don't take methylfolate. Continue with the Methyl B12 without folates ;) If your MCV and MCH are elevated signifying anemia, then you want to use Folinic Acid in addition to your Methyl B12 Do NOT supplement based on genetic variations. That's harmful. I own a supplement company and I am telling you that. It hurts my business - but it helps you. :) Read Dirty Genes - that will help you a lot. In health, |
| My doctor said I'm B12 (and Vitamin D) deficient. My number was 400 so she wants me to take 1000mcg of B12. I know your brand is reputable so I started taking it 5 days ago and for the last 4ish days my lips have been peeling, burning and the corners of my mouth as cracking. Google says it's a B12 deficiency but it didn't start until after I started the B12 supplement. Do you have any advice? Is there a better B supplement for me considering I have MTHFR? Thank you for any help you can provide, I'm so tired of navigating this world. Who knows what I need to detox after 20 years in the Navy. | Are you taking only the B12 or the B12 with Methylfolate? One doesn't supplement based on their SNPs. They supplement based on their need - such as a low level of a nutrient found in a lab test or particular symptoms. You may have a significant MTHFR variant but be absolutely fine and not need any support. Since your B12 levels are on the lower end, then I agree, you need to use some B12. Are you using this one - Methyl B12 1000: If so, consider biting it a few times, then swallowing it. Cracks in the sides of the mouth are usually due to a Riboflavin deficiency (B2). Perhaps consider using our Multivitamin One MF in addition to the Methyl B12 1000 lozenge Sometimes when you replenish a B12 deficiency, other vitamins get depleted quite quickly. Take 1 capsule of the Multivitamin One MF with a protein based breakfast every other day or on an as-needed basis. Use it only when you feel you need additional nutritional support - which is often seen as needing healthy energy, healthy mood and healthy cognitive abilities.* In health, |
| Trying to understand WHY there is NOT one of this product with a much higher MG count? 1 milligram is definitely NOT near enough. I am looking for at least 15mg if not higher. I do have the gene mutations from EACH parent... so I do need more. BUT even if it was just the one mutation... this would not even do. Confused as to why this would be it... I PREFER to use Seeking Health since I have followed Ben Lynch since 2016, and I KNOW these vitamins have NO folic acid... but I AM really saddened that this has NOT been upgraded yet? thanks for any reply that can help. | Dosage requirements are not based on SNPs. I have the MTHFR compound heterozygous variation myself. I rarely take this lozenge as it's powerful. I use Optimal Man and take 2 capsules with breakfast. That's only 100 mcg of MTHF and 100 mcg of folinic acid. We used to offer 5 mg and 15 mg MTHF but I stopped offering them. Try this lozenge and see how you feel. I'm confident you will feel it. If you don't, then I'd add in Brain Nutrients Lozenge and start with just 1/2 a lozenge upon waking. If your homocysteine levels are elevated, then look into Homocysteine Nutrients to support healthy homocysteine levels.* Homocysteine levels are essentially what dictate how much MTHF you need - not how many SNPs you have. Even that, one may have high homocysteine due to low glutathione, low B6, low B12, etc. In health, |
| I am a 59 year old Caucasian, female who weighs 103 pounds and height is 5'3. I have taken this product- one lozengier a day- for since 2014. It was prescribed for me by my psychiatrist after learning I have Heterozygous (both the C677T and A1298C are mutated). Recently, I was hospitalized for a week in a Behavior Mental Health Unit due to insomnia. I noticed a "common sign from taking too much glutathione or taking it too frequently" listed Difficulty Sleeping. Am I taking too much for my size and weight? How do I know what is proper for me? | It's not about height and weight or age. It's more about your lifestyle, food, environment. I would absolutely pause using this supplement for now and see how you feel. You can always restart it if needed. I highly suspect you are right to suspect this being the culprit to your insomnia. You can take Niacin 50 mg right now to help support a healthy response to too much methylfolate.* Be sure to take Niacin with some food. Use the Methyl B12 with Methylfolate when you feel you need additional healthy mood, cognitive or energy support.* If you are already experiencing those, then you don't need to take it. You may also find that you may do better with the Brain Nutrients Lozenge. Don't start this now as I don't want you using any B12 or folate for at least a week. If you do switch to Brain Nutrients, start with just 1/4 lozenge upon waking to support a clear head, healthy energy and healthy cognition.* In health, |
| Does consuming THC Gel tabs daily (used to stimulate appetite in person with ARFID) conflict with benefits of this product: Methyl B12 with L-Methylfolate? | I wouldn't say they conflict but they may necessitate the increased need for it. You may also find that Brain Nutrients Lozenge may be more supportive if needed - or a combination of the two. I can definitely see the THC gel tabs being helpful. Simply use more of the supplement if needed. In health, |
| I’ve noticed this product and the B complex plus make my hair very dry and causes some hair loss. Any thoughts on why this might be? I am heterozygous in MTHFR c677t and a1298c. Thanks. | I am not sure why this would be. I suspect you may be converting more testosterone to DHT (dihydrotesterone). Typically B12 and folate support healthy hair along with zinc and biotin and boron. Perhaps stop using the B Complex Plus and the Methyl B12 and Methylfolate lozenges. Switch to Multivitamin One MF and take with breakfast. The unmethylated forms of B12 and folate are more supportive of hair growth compared to methylated forms. In health, |
| Hello, my naturopath told me about you and your book that I will order. I try to have a child but my homocysteine is too high (12,7). I have the two MTHFR mutations in the heterozygous state. Unfortunately, doctors in France do not really know the MTHFR. I took tetrafolic and methyl sam to get vitamin B9 in methylated form but unfortunately my homocysteine continues to increase. I am afraid that this will prevent a pregnancy and I am afraid of the consequences it could have on my child. I don’t understand what keeps my homocysteine down. I see your product and I Wonder what is " methyl sensitive". Maybe, this is my problem but how to know? Have you got a product for me with my MTHFR mutations? I don t know what is better: méthyle B12, prénatal or an other. Thank you very much. | I recommend Prenatal Essentials. Take 1 capsule with breakfast and 1 capsule with lunch. I also would consider the lozenge you chose here - Methyl B12 with L-Methylfolate. Consider taking 1/2 in the morning and 1/2 with lunch. Additionally, take 1/2 to 1 lozenge of Glutathione Plus lozenge in the morning upon waking up. If you start getting headaches or irritability, reduce how much Methyl B12 with L-Methylfolate you are taking by 50% and also reduce the glutathione by 50%. In the beginning, you likely will do just fine with the full serving size. As your biochemistry gets supported, you likely won't need as much so you should reduce the amount taken. Your body will tell you - and so will your labs. Remeasure your homocysteine in 1 month after starting this program. If you are exercising hard, reduce how much exercise you are doing. This raises homocysteine. If you are eating a lot of protein, make sure you are not eating more than 1 gram of protein per pound of body weight. Protein makes homocysteine. If you are a vegan or vegetarian, I highly recommend eating some meat. And you should measure your serum B12 and serum folate levels or what we call here MCH and MCV. I would also take 1 capsule of Optimal PC after dinner to support healthy cell membranes and healthy homocysteine levels. A lot of homocysteine is made by your body making PC so by taking PC, you may reduce the work your body has to do and thus have healthier homocysteine levels.* For your partner, have him consider Optimal Man. It supports healthy fertility in men. He would take 2 capsules with breakfast. If he finds he needs additional support in the afternoon, he could take an additional 1-2 capsules with lunch. I usually take 2 capsules in the morning and rarely take more in the afternoon. The serving size is 4 capsules but I personally rarely do it. Every person is different. We are currently sold out of fish oil but I do recommend finding a good quality fish oil and taking that after dinner. I wish you well and a happy healthy pregnancy :) In health, |
| Hello! I have been taking methylated B12 for around 6 months and realized that I have inadvertently caused MCAS from a high B12 level as well as low Vitamin D. I have terrible skin and the symptoms of low B12 (fatigue, headaches, and neuropathy/raynaud's in hands and feet) has become much worse. I have read your book but feel as though I'm missing an important component to utilizing the b12 in my body. Glutathione? Or should I stop taking it altogether? Any help is appreciated! | I do believe you're correct in needing glutathione support. I'd consider the Liposomal Glutathione Plus and the Glutathione Plus Lozenge. I'd alternate them and see which one performs best for you. Or they both may perform well for you at different times of the day. I like starting my day with the Glutathione Plus Lozenge. Then if needing more support, you may use another lozenge or you may want to use the Liposomal Glutathione Plus. I would consider stopping the Methyl B12 with L Methylfolate for now. Have your doctor test your MCV, MCH, homocysteine and serum B12 levels. Methyl B12 and methylfolate may contribute to acne, irritability, headaches, joint pain to name a few. You may want to use the Adeno B12 form as it more is aligned with healthy energy and does not contribute to the side effects mentioned like the Methyl B12 does. In health, |
| Hi there, Is L-Methylfolate okay to take after thyroidectomy and lymph node removal due to cancer? Have MTHFR variant C677T. | You want to check with your oncologist. Once you are declared 'cancer-free', then it is a good idea to supplement with folate - but not until then. I would also look into Glutathione Plus Lozenges - and take 1 upon waking in the morning - but again - not until your oncologist declares you as 'cancer-free' I also recommend the book, Metabolic Approach to Cancer. It's very good. In health, |
| I recently start taking Methyl B12 with L-Methylfolate has made a tremendous difference in my mood and anxiety levels throughout the day. I'm also pleased to report that my senior high school child is experiencing similar benefits from the half lozenge Methyl B12 with L-Methylfolate with half of Glutathione Plus Lozenges. As she is active in sports, I was wondering if you had any further recommendations to help her perform at best. She tends to overthink and panic before races, and I want to make sure she has all the tools she needs to succeed. Any advice you could offer would be greatly appreciated. | That's great news ;) I hear you on the sports and our kids overthinking it. On race days, consider using 1/4 of the Methyl B12 with L-Methylfolate. Also - I'd consider having her try - on non-racing days first - 1 capsule of Optimal Focus. If she does well with it, then give it to her at least 1 hour prior to her race. Optimal Focus supports the feeling of a CALM FOCUS. It lasers you in without feeling that angst of a competition. My boys experience it, too. When they got on the basketball court during a game, they'd overthink and not play well. During practices, they'd crush it. Upon giving them a capsule of Optimal Focus an hour before the game, they'd walk in laser focused and with a calm feeling. On days she is training hard, I'd also have her drink 1/2 a serving of Pre-Workout Nutrients 30 minutes before training - and then sip the rest while she is training for continued periodic support. Optimal Electrolyte is another one. Use the Unflavored Optimal Electrolyte version and she can mix it in the Pre-Workout Nutrients (tastes like faint lemonade) second 1/2 of her serving and refill her water bottle. In health, |
| Is this safe for kids? I am giving my 7yo 1/4 tablet and feel like it is helpful. I am homozygous MTHFR mutation and am also taking it. Thanks! | For kids, I recommend:
Some days they may need only 1/2 a chewable and other days may need 1 or more. I like giving 1/2 a chewable with breakfast and another with lunch. Do not give past 2 PM as they won't fall asleep well. This multivitamin has the key nutrients they need - along with the B12 and methylfolate. You can give your kids the Methyl B12 with L-Methylfolate, yes. That said, only give them 1/4 a lozenge or so. Too much will make them irritable, headaches, sore joints and unable to fall asleep. I believe the Kids Multivitamin Chewable is the best way to go ;) In health, |
| Hello Dr Lynch... would this be helpful for me? I'm 70yr, tested with MTHFR and elevated homocystein levels, but my iridologist always sees my pituitary gland as needing help, always asks if i sleep well, which i don't. I don't seem to feel well on 5-htp, l. triptophane and Gaba. What would you recommend for pituitary issues if not Methyl B12 with L-Methylfolate? Thankyou so very much for taking time to help me. | For elevated homocysteine, you are correct in needing to support a healthy methylation cycle. Given that you're a wise 70 year old, stomach acid levels tend to be lower than when younger. I do recommend you use the Methyl B12 with L-Methylfolate lozenge. In the morning upon waking, take start with 1/2 lozenge.
You want your homocysteine levels to be between 7 umol to 9 umol/L. If there are above 9 umol/L, keep supporting. You may need to add Homocysteine Nutrients in addition to the Methyl B12 with L-Methylfolate if homocysteine is still not where you want it. Additional thoughts:
In health, |
| I’ve been taking this for a while and was curious about the direction. You describe it as a lozenge but a lozenge is typically dissolved in the month. Is it OK to chew instead? | Thank you for your question! You can let a lozenge melt underneath the tongue, or between the cheek and your back lower tooth. You may chew the lozenge as well if you choose, however these lozenges are intended to be melted in the mouth. We highly suggest that you re-position the lozenge frequently in the mouth to prevent uncomfortable sensation with the lozenge sitting in the same place for a prolonged period. The mucous membranes in our mouths are very sensitive, and many textures or ingredients can irritate the tissues if its unmoved. |