L-Methylfolate Dr. Lynch product Q&AUpdated 7 hours ago
| Question | Answer |
| Hi, I’m a 40-year-old active female dealing with ongoing low energy, brain fog, and low mood since ACL surgery a year ago. I’m homozygous for MTHFR C677T. My B12 is under 30, ferritin was 8 (now 68 after infusions), and homocysteine is 10. I recently started weekly methylcobalamin injections and will continue monthly for 6 months. I eat a Whole Foods, organic, grass-fed diet and have been gluten-free for 3 months, which seems to help. Intrinsic factor antibodies were negative, and my doctor suspects malabsorption, so I’ll be seeing a functional gut practitioner soon to look into root cause. In the meantime, would you recommend adding methylfolate or a homocysteine nutrients? Would glutathione lozenges be helpful? And should I continue iron supplementation even with ferritin at 68? Appreciate any insight—thank you! | Hi Debbie - I like your thoughts. Consider:
In health, |
| Sorry one more question. Here is my original question and your answer, so wondering what one of the ingredients in the products listed below is helping with the blocked pathway and be most beneficial for both the folate levels and the homocysteine? Or does it take all of them to work? Does taking beef bone broth affect this since we've added some prime bone broth to morning coffee. Thank you in advance for your knowledge and expertise. Ronda Hi, what would your recommendation be for someone with high folate levels (18.4) and B12 level 603 with a homocysteine of 11.4? Would adding more folate increase the folate, or should we support the homocysteine levels to help bring down the folate as well.? Thanks in advance. Ronda Seeking Health's Answer: Hi R.W. - This tells me there is a methylation blockage between the enzymes of MTR/MTRR for various reasons. The move is to support this intersection. Consider: Glutathione Plus: 1/2 to 1 lozenge upon waking and another 1/2 to 1 midday Optimal Electrolyte: 1 serving upon waking Homocysteine Nutrients: 1 capsule with a protein-based breakfast. Fish Oil: 1 capsule after dinner This way you're supporting the intersection of MTR/MTRR and the methylation cycle. In health, Dr. Lynch | There is hardly ever 1 thing that opens up a blocked intersection when it comes to biochemistry. You could try without the Homocysteine Nutrients and see if the folate and B12 will go down vs being elevated. I'd use the other 3 - electrolytes are key for folate metabolism and glutathione is key for both and the fish oil is supportive for healthy levels of inflammation.* In health, |
| Hi, what would your recommendation be for someone with high folate levels (18.4) and B12 level 603 with a homocysteine of 11.4? Would adding more folate increase the folate, or should we support the homocysteine levels to help bring down the folate as well.? Thanks in advance. Ronda | This tells me there is a methylation blockage between the enzymes of MTR/MTRR for various reasons. The move is to support this intersection. Consider:
This way you're supporting the intersection of MTR/MTRR and the methylation cycle. In health, |
| Hi. Dr. Ben. I was taking methylfolate 15 mg for a couple of months. Felt great. However couldn't get it for a month. Developed this peripheral nerve hyperexcitability. Twitches and headaches. Anxiety. Any recommendations? I am trying half dose of it to curb the withdrawal. | I like your thinking. I'd consider taking some Methylfolate to support your healthy brain.* I'd also be careful how much you're taking as too much can also cause those same symptoms. Consider this as well for a more comprehensive foundational approach:
This is very foundational and way more effective at supporting ALL your genes vs just using high dose methylfolate. In health, |
Hi, 2 questions. When I just changed my diet and ate foods high in folate , sometimes I would feel wired and a little tiny bit anxious. If you overdo it with foods that are high in folate could it have the same effect as overmethalation from supplements? The vitamin I take now has folate in it from the source of lemon peels- is that sufficient enough? And how would I know if it’s not? Thank you so much! | Yes absolutely. Folate is powerful. I go by how I feel and symptoms when it comes to supplementation. Lab testing can also be used and should be for certain things. You can measure MCV and MCH and serum folate. If your MCV and MCH values are right in the middle, you're good. If they are high, then you're pushing folate and/or B12 deficient. I'd also recommend looking at fasting homocysteine and you want that at around 6 to 8 umol/L In health, |
My psych said I should take between 15,000 and 30,000 methylfolate but o read I need to take b12 with it. How much b12 should I take? Maybe I don’t even need 15k to 30k. I have the double mutation for MTHFR | That's a very high amount. I recommend starting low and you can always work up as needed. Consider:
This combination is more supportive than just pushing B12 and MTHF hard. In health, |
| My daughter (almost 18) suffers from severe depression. She has the MTHFR mutation and I've been giving her 10 mg of methylfolate. I just listened to you on a podcast and realize that's too much. I'm wondering if there's one product that I can give her that will be what she needs or if there are multiple products she needs. I'm specifically wondering about your Glutathione product. I'm worried about getting products that have overlapping ingredients and overwhelming her system. Thank you. | It's too much if she's having irritability, headaches, joint pain. If she is in a better mood, and no side effects, then it may be suitable for her. 10 mg is a lot typically - and side effects are very common. Consider:
Give this a shot and let's see how she does. She may need Dopamine Nutrients as well but let's see. In health, |
Why are methylated b vitamins causing me bruxism? | Possibly because they may increase anxiousness and irritability. I recommend using them less often. Methylated vitamins are powerful and very effective. Use them on an as-needed basis. If you feel good, do not take them. I'd also consider using 1/2 the amount and 1/2 the frequency of use. In health, |
After doing the genesight test and not doing well with other treatments, I was suggested to take a b complex and 5mg of methylfolate. Week one I was over methylating— amazing energy but too much and not sleeping. Week two, exhausted and irritable. So I stopped for a few days and have only been taking b complex when I’m feeling off. Or an adrenal supplement as my cortisol/cortisone levels are off too. I have had my Dutch plus done twice but too much happening and even with suggested treatments I don’t feel the way I want to and I’m not settling for good enough! I suffer from add like symptoms- sleepy brain or when over working i have mental crashes for days. This leads to depressive moods or irritable behavior. I have high hormones — all of them (robust hormones according to doctors but could be my normal) so my moods are a little wonky in certain phases! Just feeling lost and want to feel better! | 5mg of methylfolate is a lot! And most likely too much for you. It is also not recommended to take methylfolate within 5 hours of bedtime as it may interfere with sleep. Optimal Focus can be really good waking up a 'sleepy brain' and helping with mental crashes. Start with 1 capsule a day first and see how you go. You can increase slowly up to 3 capsules per day. If you get a positive mental effect, leave it and don't take any more. See how long the effect lasts for. Once it wears off you can take more. Remember, you sometimes want to give your brain a rest so maybe don't take it on your off-days. Histamine levels also change for women depending on where they are with their hormonal cycles, so this could also play a role. If you tend to feel worse before your period you may try taking Histamine Nutrients 1-2 capsules during this time of your cycle. But I'll be honest, there's a lot going on here. Consider working with someone who can put it all together for you if you're still stuck following the above suggestions. Good luck! Elizma Lambert (Naturopathic practitioner) |
Hi, I took methyl folate for fatigue without getting any blood work, saw a video on TikTok and ordered the supplement. I am now struggling with severe anxiety and panic attacks. I have been to the ER. I stopped taking the methyl vitamins close to three weeks ago and I’m still having the same side effects. I am a 29 healthy male. If you could give me some guidance, I would greatly appreciate it 🙏🏻 | It sounds like you may be experiencing something called 'methyl-trapping'. This is when a vitamin B12 deficiency can lead to trapping an increased proportion of folate as 5-methyltetrahydrofolate. Good decision to stop the methyl folate supplement. You may want to try adding some vitamin B12 in a non-methylated form such as Hydroxo B12. Another option would be to add in Niacin. Both of these nutrients may help to reduce the excess methyl-groups that could be contributing to side effects. Let us know how you go. Regards, |
My son is compound heterozygous and takes methyl folate. I listened to your live the other day and it was in line with how I thought. Doesn’t seem normal to need to take this forever. That being said he does have a high protein diet and is a college football player, so does a lot of rigorous athletic training. Is this cause to need to continue this supplement? He and I both originally started it and methylated b12 because we are in recovery from mold toxicity, but we are both doing decently well with that now. Thank you. | If he is feeling great, then great - continue the course. Know that:
I recommend he take a look at our Pre-Workout Nutrients and Optimal Electrolyte to support healthy sport performance. He will need to add about 1/4 tsp of salt to each serving of Optimal Electrolyte as he is likely sweating a lot. And - another performance tip - have him look at highly branched cluster dextrin on Amazon. He should mix about 30 grams of this in his water bottle for games and practices. He will be invincible. It's instant carbohydrate. I used to row for the University of Washington Huskies so am very familiar with rigorous athletic training. Kudos to him for grinding it out and being a college athlete! In health, |
I need your guidance to use this product. Hello, My doctors can't explain why I am getting these numbers out of the chart even though I am not taking these supplements. I read a lot of different information on your site without being able to conclude. I have an MTHRF mutation. Should I take L-Methylfolate or not? Please, I need help! My last blood exam showed these numbers: Vit B12 - 1339 pg/mL Folate (Folic Acid), Serum - > 20 ng/mL After reading the information on your website I am thinking of trying this supplement to help me. Still, I am overwhelmed with information and unsure if this is the right supplement to help my methylation. Thanks for your support! Cleide Jost | One can have high folate and/or high B12 if not taking supplements because of (some reasons not all):
It's not possible to know if you need methylfolate or not simply based on a SNP in the MTHFR enzyme - ignore what these people say on the internet - they are wrong. I recommend reading the book, Dirty Genes. To get started with supplements, the top two I recommend are:
In health, |
| If have two mutations of MTHFR and COMT and suffer from anxiety. Should i take this version of folic or a different one | It depends on the cause of the anxiety. Anxiety may be associated with:
to name a few... I'd consider using Stress Nutrients in the morning along with Serotonin Nutrients. In health, |
I have been taking L-5-MTHF 25,500 mcg DFE once daily for years. I see that it has been discontinued. How many of the replacement “L-Methylfolate 1,700 mcg to achieve the same dosage? | That's a lot of MTHF. If you're not experiencing any side effects of anxiety, irritability, insomnia, joint pain, headaches, that's great. If you are, then you may be taking too much. You may also find that you do better with the combination of Methyl B12 with L Methylfolate Lozenges - as one needs methylcobalamin to have methylfolate work well. If wanting pure 5-MTHF, then you will need 25,500 mcg DFE / 1,700 mcg DFE = 15 lozenges to equal the same dosage. In health, |
How do you treat macrocytic anemia ? | Macrocytic anemia is associated with low folate and low B12. To support healthy B12 and folate levels, consider Hydroxo B12 with Folinic Acid Lozenge. Start with 1/2 lozenge upon waking in the morning. It can be taken with or without food. Healthy red blood cells require healthy glutathione levels and healthy blood sugar levels. Consider supporting healthy glutathione levels by using Glutathione Plus Lozenges. Take 1/2 to 1 lozenge upon waking in the morning. You may take it with Hydroxo B12 with Folinic Acid Lozenge In health, |
Is it better to take a sub linqual than a pill | Better - yes. A lozenge helps you regulate how much you need and at the same time, the ingredient 'hits' you faster than a pill. In health, |
Hi. How much of this should one take a day if pregnant and has MTHFR? | Dosage of L-methylfolate is not determined if one has a MTHFR variant or an absence of one. Dosage is based on how you are feeling and how L-methylfolate makes you feel. If you're pregnant, first of all, congratulations ;) Secondly, I recommend using:
Both of these prenatals have 800 mcg of folate as a blend. They have 400 mcg of L-methylfolate and 400 mcg of folinic acid. I'd start there and see how you feel. Measure your homocysteine levels with your doctor. You want your homocysteine levels between 7 umol/L to 9 umol/L. If your homocysteine levels are elevated, then support healthy homocysteine levels with:
In health, |