Dr. Lynch product Q&AUpdated a month ago
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| Question | Answer |
| Hi Dr. Lynch, I have been seeing a functional medicine NP who is concerned about my “high” homocysteine levels at 8.6 and my low b12 (412) and low folate (15.6). I am heterozygous C677T. My practitioner has me taking a methylated b-complex daily with a reasonable amount of methylfolate (200 mcg). However, after repeating my labs after a couple months, the b-complex did not move the needle much on my homocysteine levels or b vitamin levels, in fact the b-vitamin levels went down a little to what I mentioned above. Now she is wanting me to take a b-complex with a much higher methylfolate (800 mcg). When I expressed concern based on a bad experience when taking that high of a dose before (extreme anxiety), she recommended I take your non-methylated b-complex. She wants me to take it daily for two months and recheck homocysteine levels. I do not want to take more than I need and wanted to get your opinion on if this is the right course of action. It seems based on your past comments, you would not consider my homocysteine to be high and it did not show as out of range on my labs, yet she wants it in the 5-7 range. I respect her opinion but would also like your opinion. Thank you. | Hi Tiffany - I'm glad you reached out. Please read this article on homocysteine and share with your health professional: Homocysteine of 7 umol/L is what you want - that's ideal. Anything lower than that is too low. At 8.6 umol/L, you're barely elevated and many health professionals would say you're great. Most labs have high homocysteine starting at 15 umol/L which is way too high. Here's some things to consider:
Start here and keep me posted. I think you're overall doing great - just some minor adjustments - but nothing high dose. If you want to add in a multivitamin, consider Multivitamin One MF and take that after breakfast every other day to support all B vitamins and trace minerals. In health, |
| Currently dealing with overstimulation (insomnia, having hard time making eye contact, fatigue, forgetfulness, overall just super wired). Working on my diet …cutting out caffeine and chocolate but struggle because it does help with energy but does wire me. Any suggestions on supplements to calm me down My SNPs slow COMT , SCL6A4 +\- (don’t respond well to SSRIs), MAOB (+/+) GAD (+\+) MTHFR (+\+) | Hi Sarah - I hear you. The combination of caffeine and these symptoms is a difficult one. You feel you need the caffeine but it makes you feel worse - tired and wired. Not a nice combination. Consider:
For support with supplements:
These should support a healthy mood and healthy energy quite well and noticeably in the first day.* In health, |
| Can I split this dose in half? It would be great if you made this supplement at half this dose! I’m experiencing bad anxiety from a dose this high. Any idea what would be causing a negative reaction to this? I have slow Comt and slow Maoa and was recommended this b complex. | Hi Jack - I hear you. Yes you can. Open the capsule and mix onto a bite of food. Then close the capsule back for the next dose which you can swallow. You can also switch to the B Minus supplement. The B Minus is folate and B12 free. Then, you can use the Hydroxo B12 with Folinic Acid Lozenge and take 1/4 to 1/2 of the lozenge as needed. This way you're getting the B vitamins and you can regulate how much of the folate and B12 you need as you need. In health, |
| Hi Dr. Lynch, I previously reached out and wanted to follow up with more detail. I recently saw a functional MD who prescribed over nine supplements, including Methyl Protect (Xymogen) and liposomal glutathione (Researched Nutritionals). Initially, I felt energized (days 1–3), but by day 5, I developed chronic insomnia, rapid heart rate, irritability, and significant back and hip inflammation. I sought care for inflammation, menopause, and suspected adrenal fatigue. A saliva test showed very low cortisol in the morning (7.5 nmol/L) and afternoon (2.3 nmol/L), with normal evening/night levels. My sleep-wake cycle has been severely disrupted, which seems consistent with adrenal dysfunction and menopause. I’m starting a gentler, customized BHRT protocol. My physician recommends methylated B vitamins to support hormone metabolism, as I’ve struggled with hormone build-up and imbalance in the past. I have the MTHFR C677T variant, but my homocysteine is 6, B12 is 599, and folate is 15.1. Given my sensitivity to methylated B vitamins—but the apparent need for them—what would you suggest? I’m open to your recommendations, whether that’s one of your B vitamin formulas or something to better support my adrenals. I’m really struggling. I’ve been doing lemon water with salt and a protein-rich breakfast within 30 minutes of waking, which helped briefly, but I’m just crashing out all day long and I get a bit of second wind at night. Any guidance would be deeply appreciated. -Stacey | Hi Stacey - You're not alone - sorry about this. I trained many MD's but not enough... A few things to consider:
Start here and keep me posted. In health, Read this article on Methylfolate: Read this article on Methylfolate side effects: |
| Hi Dr. Lynch, I recently saw a functional MD and I walked out with over 9 supplements, one of which Methyl Protect by Xymogen and liposomal glutathione by Researched Nutritionals. Days 1 - 3, I thought I could take on the world, albeit some insomnia. By day 5, I had chronic insomnia, rapid heart rate, irritability and severe inflammation/pain in back and hips (which is why I sought out a functional doc in first place). I recently had full bloodwork which revealed I have the MTHFR C677T variant, however, my homocysteine levels are 6 and my B12 was 599, folate serum was 15.1. I stopped both the methyl protect and the glutathione and am reluctant to start anything else they gave me. I bought your book and am waiting for that now, but in the meantime, I feel like I need a better plan than this. | Hi Stacey - What you're sharing is what is happening to SO MANY people. I'm so happy you reached out. Please read my book, Dirty Genes. I'm glad you have it. Also - please read this article - it will answer a ton of questions and help you understand how to supplement. Glutathione and methyl donors can cause exactly what you're experiencing. 'Having a MTHFR variant' is like having a red sports car. You're more vulnerable to things - like homocysteine - which yours is perfect - or getting speeding tickets. Just because you a have red sports car doesn't mean you have to pay for a speeding ticket each time you drive. You're just more vulnerable to them. Having MTHFR makes you vulnerable to high homocysteine but it may be totally fine. Your homocysteine is fine. So don't take those supplements. No idea why you were prescribed them if your homocysteine was 6 - that's a poor recommendation. Most likely because 'you have MTHFR'. In health, |
| Hi there, I am currently taking Serotonin Nutrients in the morning with breakfast for mood throughout the day. I’m curious when would be the ideal time to take this B Complex in relation to when I take the Serotonin Nutrients, because they both contain Niacin and I’m trying to avoid the flushing. Should I take it with lunch? Thank you! | Hi Morgan - If you take with a meal, you're good. We use a combination of flushing and non flushing niacin so you should be fine. If you do flush, it would only be once or twice and then your body will adapt. I doubt you will though if taking these after a meal. Make sure you have a solid protein based breakfast - not just dry cereal and milk. Meat, eggs, protein based smoothie with frozen berries - something like this. Use them as needed - not daily. On days you feel great, do not take anything unless your doc says to. In health, |
| Hello, Is it possible to pour half the contents into an empty capsule or is it recommended to add it to food instead? | Hi Jenna Which ever way you prefer. Both are fine. In health, |
| I tolerate these methyl free B vitamins much better than others. They don’t give me anxiety/jitters like other ones, however I’ve noticed I get a headache several hours after taking these. Any recommendations on what I need to change or additional things I could use to support my body? I’m already taking the histamine probiotics, histaminX, DAO enzymes, digestive enzymes, colostrum and magnesium glycinate. | Hi Amanda - I suspect you may simply need these less often or only 1/2 a capsule mixed into a bite of food and less often - both. OR You may want to remove the B12 and folate completely and switch to B Minus. B Minus is a B vitamin complex without any B12 or folate. I find many people, especially who are high histamine, are intolerant to folate and B12 for various reasons - and many I don't know why. I'd pause the B Complex MF for now - say for a full week. Switch to B Minus. Then consider:
In health, |
| Hello, I just recently found out I’m slow COMT and I know I’m most likely deficit in many supplements. I ordered the mf bcomplex but I’m not sure if I made the right move. I’ve been having super bad anxiety out of nowhere for the past 3 weeks to the point it’s crippling. Constant anxiety, panic, and really horrible sleep. I’ve also always got headaches mostly everyday since I’ve been about 15. Some. Days are better than others but it’s pretty rough. I’m currently on buspirone and I’m not liking it much as it’s causing super bad headaches even at a low dose. I’m a stay at home mom so money is super tight so it’s hard for me to trial and error different expensive meds. | Hi Olivia - I hear you. Buspirone works by stimulating serotonin receptors. High serotonin activity can be associated with headaches. Headaches daily can be caused by a number of things:
Consider:
In health, |
| Dr. Lych, I took the histamine stratagene report. I have been struggling with what I can only assume is histamine intolerance. I tested positive for chemical allergies and have since switch over to fragrant free products. We just ordered a whole house water filtration system. Our air quality was tested and is normal. Had a company come out to clean our air ducts, but they said they don't need it. I still have itchy eyes and around my mouth, whether I am inside the house or not. I have been taking all of Seeking Healths histamine products and have not had a break in my symptoms. The histamine stratagene report states the my HNMT Route is elevated and most everything else is somewhat elevated or typical. Most of the supplements recommended to clean HNMT routed (and others) are B2, B5, B6 and B12. I do not tolerate folate or methly vitamins. I am not sure which B supplement I should take from Seeking Health or if I should take each B vitamin separately to avoid reacting to them? I really want to support my histamine pathways because what I have been doing doesn't seem to be working. Thank you for any advice! | Hi Jen - Good to hear that you're making some significant moves towards reducing histamine load. I recommend ordering the US Biotek 96 Common Foods IgG test Ask your doctor to order it for you. Did you get the Histamine Workbook? Work through each checklist and knock one off as you can and keep working on it.
When was the last time you were better? What changed? Consider:
In health, |
| Hi, I was wondering what your advice is on replacing B vitamins with Grassfed Beef Liver Capsules for supporting a heterozygous MTHFR gene? Or alternating between them, as in one day the B vitamins, then next day the Beef Liver? Or would I need B vitamins at all if I ate enough liver? I'm trying to go as natural as possible, but am not sure if the Beef Liver would be enough support. Thank you :) | Hi Jamie - The beef liver can be great - but it's not quantified. One does not know how much of any B vitamin is in there. It varies batch to batch and bottle to bottle most likely - just like the nutritional content of food. The only way to tell is by taking the liver capsules and seeing if that's enough for you. It may be for some days and other days it may not be. On the days you feel you need additional support, then take a capsule of B Complex MF. Please keep in mind - top of mind - that you do NOT need to supplement because you have a MTHFR variant. You supplement based on a NEED not a SUSCEPTIBILITY. So many people oversupplement because they 'have MTHFR'. Most of us have a MTHFR genetic variation. If you're eating really well, living well and your homocysteine levels are between 7 - 9 umol/L, you do not need additional folate or B12 likely. Please read this: In health |
| I have used 1/4 of folinic & b12 and still headache and agitation. I also purchased methyl free b’s and just did about 1/4 of capsule a few days later and I noticed I felt tired vs uplifted. My mg and potassium levels are good. My vitamin d was low and working on that. I’m stumped why I am having paradoxical reaction to the b’s no matter gow small yet my homocysteine is 14. Def can’t do methylated. I am also very choline and sulfur sensitive. Choline makes me very lethargic, agitated and depressed… even high choline foods in larger amounts. Thanks in advance for any guidance. | Hi Stacey - I suspect your microbiome is off and contributing to many symptoms. Have you tried single B vitamins like:
These both support healthy homocysteine and may support you without having side effects. Consider:
This is a gentle approach to support your homocysteine metabolism. Introduce one supplement every couple days - by itself - to see how you respond. Do not add one supplement on top of another. Just one at a time. In health, |
| Thank you for the advice on the folate. I have always seemed to be super sulfur sensitive also. Tried glutathione multiple times with horrid results. I just go the lozenge last week for another go and I am taking 150 mcg of molyb twice a day and 1/4 lozenge of your glutathione 3 times in the last week and I felt my head clear almost immediately. ZERO reaction also. I have also been taking your DAO 3 times a day and already drinking electrolytes. I really need to add in some B’s to get that homocysteine down a couple points. I absolutely have histamine issues. Thank you so much! Appreciate all the education you provide. | Hi Stacey - Brilliant :) One thing I've noticed with homocysteine, and read in the research which is very interesting:
"The administration of folinic acid compared to l-methylfolate caused a higher increase of serum folate levels but no difference in the reduction of serum homocysteine levels. The reduction of serum homocysteine levels was influenced by the MTHFR C677T and not MTHFR A1298C gene polymorphisms. The individuals with MTHFR 677CT genotype appear to benefit more when supplemented with folinic acid than l-methylfolate." I've been experimenting between taking the Methyl B12 with L-Methylfolate lozenges and the Hydroxo B12 and Folinic Acid Lozenges. I have MTHFR compound heterozygous meaning I have 1 x 677 and 1 x 1298 variant which reduces my MTHFR enzyme function by upwards of 70%. I feel my head clear way better when using the Hydroxo B12 with Folinic Acid compared to the Methyl B12 with Methylfolate. I still feel better when taking the methylated forms - but there is noticeable improvement when I'm using the unmethylated forms. I invite you to try the Hydroxo B12 with Folinic Acid Lozenge and start with 1/4 to 1/2. I notice I feel better at the moment using a full lozenge a few times a day - which is quite a bit - but needed for now for some reason. I suspect it has to do with a persistent virus in the world which increases homocysteine. In health, |
| My homocysteine is 14. I am super sensitive. I can’t take methylated vitamins at all and even crushing up the folinic acid lozenges and taking small pieces makes me feel agitated. How do you lower homocysteine if you are this sensitive? I do ok with 1/4 of the hydroxo B12. Will starting with a sprinkle of this begin to lower my homocysteine? I feel stuck. Thanks! | Hi Stacey - I believe the sensitivity to folates is a few things:
Do not order these or take these all at once. I'd start out first with the Optimal Electrolyte as it's the most supportive foundationally. Then move to the Glutathione Plus Lozenge as it's supportive foundationally as well. Make sure you are fasting when you measure your homocysteine levels - and do not have a large high protein dinner the night before. In health, |
| Im unable to swallow pills at all. Can I pour this powder into a smoothie or water? | Yes, you can. It may not taste very nice though. B vitamins are notorious for their best taste. But you may be able to disguise it enough. If it doesn't work in a liquid, then you can try mixing the powder in a bit of apple puree or raw honey. Regards, Elizma Lambert (ElizmaLambert.com) |
| I normally use B complex with chlorine and ordered the B Complex MF. After using it for a week or so I started getting a headache and a little vertigo. I do have MTHFR. Any suggestions or reasons why. Karen | Our B Complex is quite potent. Use it less frequently and you should be good to go. You're taking too much and too often. Consider:
OR
I take Optimal Man, a multivitamin for men that has lots of B vitamins, only about twice a week. I feel I don't need it otherwise. In health, |
| In this B complex MF, why is the folinic acid (or methylfolate in the b complus plus version) such a small dose? What was the formulation reasoning for only being 400mcg? | Active folates are very powerful. It does not take much to feel an effect. Believe me, you take one capsule of these with a meal, you're going to feel it :) In health, |
| Hi, I am Homozygous C677T (so double MTHF gene variation), I have Hashimoto's, Hypothyroidism and high Homocysteine. I also have no gallbladder :( I'm wanting to know what products in your range are best for me? Can I take B Complex MF aswell as Homocysteine Nutrients or do you take one or the other? Also what are the best supplements if you don't have a gallbladder? It is a rare day that I feel 'well' and have energy so I'm willing to try anything that might help. Thank you in advance for any assistance you can provide. | A few things I suggest:
Start here. This should provide significant improvements within a day or two. In health, |
| Hi there - I just took my first dose of B Complex yesterday with lunch. I was awake all night! Could it be from this? I also took HistamineX and DIM with my lunch. and Molybdenum at dinner. I have several gene mutations. Slow COMT, fast MAOA, DOA, PEMT....etc. I am trying to focus on fixing migraines. | Yes ;) - sorry! The slow COMT will definitely keep you up at night when taking a potent B Complex like ours. Here's what I suggest you consider:
This is a comprehensive plan to support healthy blood flow to your head. It's focusing on many areas which may be - and likely are - contributing to blood flow issues. If you're still struggling after this a bit, consider Serotonin Nutrients. Low serotonin is a migraine trigger and a fast MAOA increases one's clearance and elimination of serotonin. That said, we also need to know how fast you make, transport, bind serotonin - and your StrateGene Report will show this. If you don't make much serotonin, slow to transport it, slow to bind it to receptors, reuptake it quickly and eliminate it fast, then that's a likely life long reason for migraines. A slow COMT is associated with migraines as well due to the estrogen - especially if there is a big estrogen spike followed by a big estrogen drop. The bigger the estrogen change, the more likely a migraine - especially two days before menses and up to the 3 days after. By taking DIM prior to menses and then stopping 2 days prior, that would support healthy estrogen levels.* The magnesium found in Optimal Electrolyte is also key for healthy COMT function. In health, |
| Hi! I have slow COMT and 60% reduction of methylation (due to MTHFR genes). I was told this product would help. This is day 1 of me taking it and I felt SOOO much energy but it almost feels like too much? I’ve been go go all day which is AWESOME (have not felt this good in awhile) but it seems like I can’t relax. There’s some racing thoughts, some nausea, dry mouth and anxious feeling. Is this just my body adapting? It’s not horrible, I’m just Curious what I should do as I definitely feel weird, but want to stick with it since it’s genetically what I’m supposed to be taking. Can someone respond as soon as possible? Thank you so much!! | Glad to hear that the B Complex MF has given you more energy :). However, it seems maybe a little too much? I suggest you try it at 1/2 capsule per day and see how you go. Open up the capsule and mix half of the powder into a bite-size of food. It may be that you only need half the dose or that splitting the dose over the day works better for you. You don't need to take more than what your body needs. Let us know how you go :) Regards, |
| Hello, I just started this supplement, and haven't given it sufficient time to know if it works yet. But I am switching to this from Thornes methylated B multi. I have migraines often and was wondering if it was the B vitamins I was taking. Still getting them now that I switched to B Complex MF and wondering if I should stick with it? Is there an initial detoxification that happens that could be causing the migraines? I also ordered some Calcium D-Glucarate and Dim to try as well because I think I have estrogen dominance. | Migraines are associated with:
Consider:
Keep me posted on how you're doing. You should notice changes within a day or two tops. In health, |
| Hello Dr Lynch, Support suggested I send my question on balance/dizziness issues from possibe hydro cephalus to you hear. Hello, I was just diagnosed with NP hypocephalus . I will be having a lumbar tap to verify. In the meantime can you suggest anything for the balance and dizziness symptoms? I am a 70-year-old female with CFS/ME, Fibro, MTHFR6777 and hypothyroidism. My blood pressure is normal, no diabetes, and weigh 145lbs. Thank you, Marion | This requires more guidance than I am unable to provide and it's out of my area of knowledge. I recommend looking for a health professional who is a licensed naturopathic physician or functional medicine doctor. In health, |
| My husband currently takes a Ortho Molecular product called Ortho B Complex snd noticed it has Folic Acid in it - is your B Complex MF a better choice ? He had two mutations C677T and A1298C | One does not want to be taking folic acid. What I recommend for your husband is stopping the B Complex with folic acid. Then, consider:
That combination will be quite supportive for him - better than the B Complex MF In health, |
| Hi Dr Lynch, Just following up on the questions regarding B Complex MF I sent last week, as I haven’t yet heard back from you. I wasn’t sure if they were sent through successfully. Your assistance with the questions below is much appreciated. 1) I noticed that the 'Suggested Use' on the bottle stated not to take it with Multivitamin. I need to take my Beef Spleen & liver capsule supplement (in a natural form) everyday as a form of Multivitamin. Could you please advise if it is still okay to combine with the B Complex MF? The Nutritional facts is attached on the Profile picture for your reference. 2) Can I take this B complex with coffee as we know coffee will deplete vitamin B? 3) I am currently also taking the Hydroxy B12 and Folinic acid Lozenges x 1 tablet (and Optimal glutathione Lozenges x 1 tablet) for high homocysteine issue caused by c677t gene mutation x 2 copies. Please advise with combining the B Complex MF, am I taking too much? 4) The 'Suggested Use' on the B Complex MF bottle also stated only take it when necessary. Can I take it everyday? Thank you for your time. Best regards, Esther Wong |
In health, |
| My son is COMT-G304A-homozygous negative,G472A heterozygous-AHCY C112T homozygous negative,G367A homozygous negative,g.G32878481C homozygous negative-MTRR-A66G heterozygous-MTR A2756G homozygous negative,C3518T homozygous negative-MTHFR-C6771 homozygous negative A1298c homozygous positive….what do you recommend? He suffers from racing thoughts intrusive thoughts anxiety, derealization and depersonalization disorder as well…he is currently on 10c health protocol but don’t feel it’s working…he takes 5-mthf and a optimize multi vitamin…..I just ordered him your skin nutrients since he suffers from acne he got of accutane because we feel it affected his mental health as well I want to switch to your products….thank you So much we are at our wits end watching him suffer and hear him say he just doesn’t feel normal | I'll be honest in that I'm not sure what you mean by 'homozygous negative' and 'homozygous positive'. I'm also not sure what the '10c health protocol' is. In my experience protocols are rarely the answer. You can have 10 people with the same symptoms / condition, but use a different treatment option for each due to differing genetics or biochemistry. The symptoms you are describing for your son indicate dysregulation of brain dopamine and possibly norepinephrine. He seems to have symptoms of both low and high dopamine which could indicate possible dopamine receptor or breakdown issues. I suggest Brain Nutrients, but am reluctant to suggest anything more specific as your son is in a place at the moment where the wrong supplement could make him significantly worse. More information is needed here. I highly recommend that you work with a healthcare practitioner experienced in nutrigenomics and mental health. Skin Nutrients is a good choice. You may also add in Histamine Digest to complement the Skin Nutrients. All the best :). Regards, |
| Hi Dr. Lynch I am heterozygous for the C677T variant and negative (normal) for the A1298C variant in the MTHFR gene. I am also low COMT. I also suffer from severe fatigue, migraines, brain fog and anxiety for a long time. I have been doing a lot of research and trying to figure out what is best to supplement with now knowing the my gene mutations. I have wasted a lot of money and time on many supplements that haven't helped in the past so I'm hoping you can recommend if this B cIomplex MF would be a good fit for me to try or do you recommend something else? Thank you in advance Ann | There are many reasons why one may experience these symptoms. It is a good idea to work with a health professional to get to the bottom of it by looking at labs and thorough history. Making recommendations purely based on SNPs and gene mutations is not something I recommend - it's full of errors. Based on your symptoms, I can make some gentle supportive recommendations that may be helpful:
I don't like recommending a B Complex out of the gate as they can be pretty potent. Starting here is a good approach. In health, |
| Hi, I opted to try B Complex MF because I am overly sensitive to other B Complexes. If I take daily, I experience the nervousness, anxiety, heart palpitations etc. and even once every few days, contributed to constipation. I took B Complex MF once last week. I got a headache and brain fog. I also felt a bit anxious. Is this related and would you suggest I try it again? | I don't recommend you try it again. I feel you are getting too many B vitamins that your body and brain do not need. There is likely something else you need and it doesn't appear to be B vitamins. In health, |
| Hi, I saw your podcast on Dr Tyna and have been reading your information. I’m excited to read your book. For the last 7 yrs my vitamin B12 serum has been very high and out of range of 1500+ (Dec 2023 it was1422) . I was wondering if this is covered in your book? After 3 doctors & an oncologist testing dozens of labs I was told high B12 is fine and there are no health concerns to come back in 6mos and check my levels again. Through my own research I found that MTHFR is the cause. I am heterozygous for the C677T variant and negative (normal) for the A1298C variant in the MTHFR gene. I am curious if I start supplementing with the B MF should I start slow? Will this lower the levels in my blood? Im not sure how the process works. I’m also curious if this isn’t in your book if you know where I can find more information on this. I can’t seem to get help from a practitioner and really want to make sure I’m doing what I can since I feel like I’m deficient in B12. Also do you recommend I test my 7 & 9 yr old boys for MTHFR ? And supplementing them? They do have trouble concentrating at school during tests. We really focus on supporting their diet and sugar intake but I’m just curious since I’m in learning mode. Thank you, Erin | Glad you're enjoying Dr. Tyna's podcast. She's awesome ;) Enjoy Dirty Genes - it's going to empower you immensely. In terms of high B12, I may touch on it. Here's some additional information on reasons why B12 may be high:
MTHFR may be a contributing cause of high B12 levels because of low methylfolate levels. Again, if MTHFR enzyme is not producing sufficient methylfolate, then methylcobalamin cannot do its job and the B12 gets stuck and levels show up. If you take methylfolate, along with glutathione, then you may find your B12 levels normalize. Consider:
For your kids, consider:
In health, |
| Not really a question, but a wish for a B-complex without B6, but if that's unsound, then only a very small amount. Why? After having B6 toxicity and the horrible burning feet pain, sometimes freezing cold, and I was using the P-5-P form. I didn't realize B6 is found in many foods, so any amount in addition to more than we need leads to B6 toxicity. The bad thing is that B6 stored in muscle, so not as water soluble as the other B vitamins. I could really use such a B-complex as my homocysteine is above range, but the B6 runs me off. (P.S.- I am not diabetic.) | I hear you. Thank you for sharing your wishes and thoughts. "Pyridoxine is stored primarily in the liver, with smaller amounts in the brain and muscles". This suggests that while P5P can be stored in muscles, it's not the primary storage location. B6 is an interesting vitamin and, in some people, it can contribute to symptoms. I do not believe it is all people. I will ponder how to update or add another B complex with lower B6 or none. Thank you Dr. Lynch |
| It says methyl free but I notice there is inositol in there as part of the niacin. I saw on your blog that inositol has methyl so I am a little confused. Thank you for clearing this up. | Inositol hexanicotinate is not the same as inositol. It's a methyl-free B complex :) Great question. In health, |
| I have been concerned about my high homocysteine levels, so for several months I have been taking a B complex that contains methylated B vitamins, along with 4 grams of TMG daily. I have become very nervous and anxious, so your article stating that some people do better on Methyl-free B vitamins was an eye-opener. My three questions are: 1) Will your B Complex MF reduce homocysteine? 2) If the methylated B vitamins make me anxious, should I stop taking TMG because it is methylated? 3) If so, do you have a substitute? Thanks in advance for any clarification on this! Amanda | B Complex MF does support healthy homocysteine levels yes because it contains B6, active folate as folinic acid and active B12 as hydroxocobalamin and B2 which supports MTHFR. I have found that TMG is often well tolerated by those sensitive to methyl donors. I'd consider the B Complex MF along with the TMG. You may also want to just try the TMG by itself. Additionally, I'd add in 1/2 to 1 lozenge of Glutathione Plus Lozenges to support healthy glutathione levels.* High homocysteine may occur because of low glutathione levels. Additionally, dehydration or electrolyte deficiency can also contribute to high homocysteine. I'd support with 1 glass of Optimal Electrolyte once or twice daily. Sip it in a glass of filtered water to support healthy hydration.* The Optimal Electrolyte also provides creatine is a healthy amount which supports healthy methylation. You may also benefit from taking Optimal PC - 1 capsule after dinner - to support healthy methylation, bile production and a healthy mood and healthy homocysteine levels - all in one.* The bulk of homocysteine production comes from making creatine and PC - so by taking creatine and PC - one may experience less demand for methylation thereby reducing levels of homocysteine.* In health, |
| I have been taking B Complex MF for a year or so, but I noticed lately that I was feeling like I didn’t have the energy to walk even 20 feet. I decided to go off all vitamin and minerals supplem to see if any were causing this. It turned out it was the B Complex MF. This lack of energy was even evident when I took only a very small amount. I’ve been off it for a couple of weeks and have a normal energy level again. I tried the methylated version before and had to change because of headaches. I’d rather not buy all the B vitamins individually to see if it is just certain ones causing this reaction, so I’d appreciate any advice you can give me. Thank you! | I'm glad you pin pointed this. I suspect it may be the Niacin doing this. It's tough to say though as there are so so many variables and enzymes that may be overly active and contributing to fatigue in your case. What I do recommend applying is the Pulse Method: Most supplements are not designed to take every day - especially B vitamins and multivitamins. I take Optimal Man just a few days a week and only 2 capsules with breakfast. If you have any specific questions wondering if another product may support whatever situation you're having, please ask on that specific product page. I'll do my best to support you. In health, |
| What gene or multiple genes will tell me if a person is methyl sensitive and needs to not use Methylated vitamins and supplements? | It's not that easy. I wish it was. One can have typical genes but these genes may not be functioning well due to nutrient deficiencies, chemical exposures, infections to name a few. I recommend reading the book, Dirty Genes to get an understanding of this. All health professionals also get free access to the Membership. I'd watch the SHEICON series or the Methylation and Nutrigenomics Conference recordings. I usually determine giving a MF supplement or a methylated supplement based on symptoms. Methylated nutrients = lack of drive, low mood, low energy, poor cognitive abilities MF or unMethylated = easily stressed out, emotional outbursts, you're not sure which one so you want to be more gentle in your approach In health, |
| Wederom dank, Met sup voor galblaas begonnen. Echter aangezien ik toch net iets te weinig b9/ b11 binnen krijg dmv voeding ga ik toch de folinic acid en hydro- adeno b12 lozengo's bestellen en er een klein stukje van af breken. Of is het echt niet aan te raden al te beginnen? (B2 neem ik trouwens ook daar ik hiervan zeer weinig binnen krijg dmv voeding). Dus deze omzetting van folinic acid zou makkelijk gaan ondanks genetisch slechte omzetting? Zou ik ooit wel weer de methyl vorm kunnen verdragen? Hoe lang histaminx door blijven slikken ?ik gebruik deze al een tijdje Thanks. Kind regards, Patricia | Thanks again, started SUP for gallbladder. However, since I get just a little too little B9/B11 through food, I am going to order the folinic acid and hydro-adeno B12 lozengos and break off a small piece of it. Or is it really not advisable to start already? (I also take B2 because I get very little of it through food). So this conversion of folinic acid would be easy despite genetically poor conversion? Would I ever be able to tolerate the methyl form again? How long should I continue taking histaminx? I have been using this for a while. Thanks. Kind regards, Patricia Hi Patricia - If you feel you should start the Folinic and Hydroxo/Adeno, you may - and I agree to start with a small amount. Tolerating methyl groups is a complicated subject and full of theories. I am still learning what makes one more susceptible to methyl donors and more tolerant. I suspect it has to do with histamine and serotonin and dopamine levels - and how much potassium, glutathione and magnesium are on board. In health, |
| Hi hi, Excuses, bedoeld u de ox bile? Dat lijkt mij wel wat. Deze kan ik dan beter via een Nederlandse online winkel bestellen als ze deze hebben. Kind regards, Patricia | Do you mean the ox bile? That seems like something to me. I would be better off ordering these via a Dutch online store if they have them. Kind regards, Patricia Hi Patricia - Gallbladder Nutrients is the better option over Ox Bile. You can try Ox Bile first but I do believe the other is better suited. In health, Hallo Patricia- Galblaasvoedingsstoffen zijn de betere optie dan Ox Bile. Je kunt Ox Bile eerst proberen, maar ik denk dat de andere beter geschikt is. Op het gebied van gezondheid, |
| Hi hi, thank you very much for your answer. Kan ik gewoon de l- carnitine nemen ondanks slechte aminozuren methylatie? Ik krijg ca 100 gr eiwit dmv voeding binnen ( voorheen meer 120- 140 maar dat durf ik nu niet meer goed aan ). Gluthation heb ik en mee gestopt na reactie van al een klein mespuntje. Ik overweeg het desondanks opbouwend weer te gaan nemen. U bevestigd dit gelukkig. En krijg ik niet te veel antioxidanten binnen dan, ik krijg al veel dmv voeding binnen; ivm met hun invloed op de schildklier met name bij menopauzale vrouwen? Krijg wel ca 250-300 jodium binnen. Sup voor de galblaas ga ik mij in verdiepen want is wel nodig.Had ook weinig gal in darmmicrobien onderzoek. Ik heb ook nog paardebloemextract tinctuur , is dit wat of beter die wat u adviseert? Betreft de b vitamines; vit b2 krijg ik veel te weinig binnen en suppleer ik bij. Folaat vaak ook net iets te weinig. Desondanks wachten ermee? Thank you. Kind regards, Patricia Verdriet | Can I just take the l-carnitine despite poor amino acid methylation? I get about 100 g of protein through food (previously more 120-140, but I no longer dare to do that). I stopped using glutathione after a reaction from just a small pinch. Nevertheless, I am considering taking it again in a constructive manner. Fortunately you confirmed this. And I don't get too many antioxidants, I already get a lot through food; in connection with their influence on the thyroid gland, especially in menopausal women? Get about 250-300 iodine. I will look into SUP for the gallbladder because it is necessary. Also had little bile in intestinal microbe research. I also have dandelion extract tincture, is this something or better the one you recommend? Concerns the B vitamins; I don't get enough vitamin B2 and I supplement. Folate is often just too little. Nevertheless, wait? Thank you. Kind regards, Patricia Verdriet Hi Patricia - The Gallbladder Nutrients contain dandelion root so yes, I do recommend this herb to support your needs. I highly recommend you start with Gallbladder Nutrients first before adding other vitamins. Take 2 - 4 capsules before dinner. Do this for 2-4 weeks. Then, you may add a capsule of B Complex MF with breakfast. In health, Hallo Patricia- De galblaasvoedingsstoffen bevatten paardenbloemwortel, dus ja, ik raad dit kruid aan om aan je behoeften te voldoen. Ik raad u ten zeerste aan eerst met galblaasvoedingen te beginnen voordat u andere vitamines toevoegt. Neem 2 - 4 capsules vóór het avondeten. Doe dit gedurende 2-4 weken. Vervolgens kunt u bij het ontbijt een capsule B Complex MF toevoegen. Op het gebied van gezondheid, |
| Hi hi, allereerst mijn complimenten voor uw boek, ben deze aan het lezen. Vraag betreft mf b complex; - kan ik deze capsule openen en de poeder los nemen? Is deze maagvriendelijk? Ik hou niet van hele hoge dosissen namelijk. - hoeveel niacine zit er in deze? Niacine krijg ik dagelijks ook erg veel van binnen dmv voeding. Alleen b2 te weinig en folaat rondom de adh (vanwege lactoseintollerantie). Ik heb onder andere 1 allell homocygote enb1 heterzygote mthfr , Trage comt, trage pempt , Trage gstm1 en meer. Ik herinner mij dat bij 1 van deze ,pemt, geloof ik hoge dosis b3 ook afgeraden wordt? Is het beter alle los te kopen? Of het complex zonder folaat en b12 en deze laatste 2 los kopen? Kan ik gluthation nemen daar mijn aminozuren vertraagd verwerkt worden? Mijn zweet ruikt al naar ammoniak en nu iets geminderd met vlees/ eiwitten. Hartelijk dank 🍀 Kind regards, Patricia | Hi hi, first of all my compliments for your book, I am reading it. Question concerns mf b complex; - can I open this capsule and take the powder loose? Is this stomach friendly? I don't like very high doses. - how much niacin is in this? I also get a lot of Niacin every day through food. Only B2 too little and folate around the ADH (due to lactose intolerance). I have 1 allell homocygote enb1 heterozygote mthfr , Slow comt, slow pempt , Slow gstm1 and more. I remember that with one of these, pemt, I believe a high dose of b3 is also not recommended? Is it better to buy them all separately? Or buy the complex without folate and b12 and the latter 2 separately? Can I take glutathione as my amino acids are processed slowly? My sweat already smells of ammonia and now slightly less meat/protein. Thank you very much 🍀 Kind regards, Patricia Hallo Patricia- Ik zou me eerst concentreren op het ondersteunen van uw lever- en darmgezondheid. Waarschijnlijk komt hier de ammoniak vandaan. Overwegen: Voedingsstoffen voor de galblaas: Neem 2 capsules vóór het avondeten om een gezonde galproductie en -stroom te ondersteunen. Acetyl L Carnitine: neem 's ochtends 1 capsule bij het ontwaken om een gezond vetmetabolisme, ammoniakmetabolisme en energieondersteuning te ondersteunen. Glutathion Plus Zuigtablet: neem 's morgens bij het ontwaken een halve zuigtablet en laat deze oplossen. Slik dan. Dit ondersteunt gezonde mitochondriën. Magnesium Plus: Ik zou een van deze voor het slapengaan nemen om een gezond ammoniakmetabolisme en slaap te ondersteunen. Als u deze een paar weken aan de gang heeft, kunt u overwegen een B-complex of een multivitamine toe te voegen. U kunt het het beste doen met de Kids Multivitamin Chewable MF. Dit bevat je B-vitamines, sporenelementen en enkele antioxidanten. En u kunt indien nodig gemakkelijk op de heerlijk smakende tablet bijten. Op het gebied van gezondheid, -- I would first focus on supporting your liver and gut health. This is where the ammonia is coming from most likely. Consider: Gallbladder Nutrients: Take 2 capsules before dinner to support healthy bile production and flow. Acetyl L Carnitine: take 1 capsule in the morning upon waking to support healthy fat metabolism, ammonia metabolism and energy support. Glutathione Plus Lozenge: upon waking in the morning, take 1/2 lozenge and let it dissolve. Then swallow. This supports healthy mitochondria. Magnesium Plus: I'd take one of these before bed to support healthy ammonia metabolism and sleep. Once you get these going for a couple weeks, then you may consider adding in a B complex or a multivitamin. You may do best actually with the Kids Multivitamin Chewable MF. This has your B vitamins, trace minerals and some antioxidants. And you can easily bite the great tasting tablet as needed. In health, |
| I really like this as I have bad reactions to methylated vitamins. But I'm wondering if there is a version without b6? Or how to avoid b6 toxicity? | B6 toxicity isn't really a thing. I'm not sure who started this on the internet but it's inaccurate information. High B6 levels are typically associated with the microbiome. The high B6 does not contribute to nerve issues. It may be 'associated' with nerve issues but it's not causative. Your bacteria in your gut make water soluble vitamins - which then get absorbed and appear on your lab test. I recommend supporting your microbiome by using 2 capsules of Gallbladder Nutrients before dinner. Then taking ProBiota HistaminX after dinner. I'd use the B Complex MF or even the B Minus with breakfast. B Minus is a B Complex that is free of all B12 and all folate. The B6 levels will go down once your gut health is restored. In health, |
| I have been dealing with constant dizziness/ feeling off balance (rocking on a boat feeling) for a long time. Some days it not as bad but it's always there. I was originally diagnosed with adrenal fatigue but we treated that and I'm still dizzy. I recently started some of your supplements for Dirty Dao because I have alot of those symptoms. I'm also compound heterozygous mthfr so I'm thinking possibly high homocysteine too since I have several of those symptoms including estrogen dominance. Would you recommend b vitamins to help the dizziness or you think I need something else? Thank you 😊 | A Dirty DAO definitely may be associated with a feeling of dizziness or boat rocking. I recommend supporting healthy histamine levels. High estrogen levels promote histamine release and activation so that needs to be addressed, too. Look into: DIM+I3C: take 1 capsule any time of day or night with some food. Optimal Electrolyte Unflavored: sip this upon waking in the morning. Id add a pinch of salt to it. Glutathione Plus Lozenge: consider 1/2 lozenge immediately upon waking up in the morning. Few other things: Talk with your doctor to check your serum ferritin, chem panel with diff, MCV, MCH, thyroid, sodium/potassium ratio, fasted homocysteine levels If you find yourself peeing frequently, you may be low in minerals and electrolytes. This is why I recommended electrolytes to support healthy electrolyte levels. You may also want to consider taking Multivitamin One MF with breakfast every other day as it supports all your B vitamins and trace minerals. In health, |
| Can one open the capsule and pour contents, if difficulty swallowing, Thanks | Absolutely you can. I recommend pouring the contents onto a bite of food - vs a drink. The taste of B vitamins is not good ;) Then chase the bite with another bite of food. Mixing in a bite of organic applesauce could be good - and you could follow it with a bite of real food afterwards. In health, |