DIM + I3CDr. Lynch product Q&AUpdated 5 hours ago
| Question | Answer |
| Can I take this if my bad estrogen is high but my good estrogen is on the lower side? If so, how many capsules a day and throughout my whole cycle if trying to conceive? | Hi Ayse - There are a few bad estrogens. Estrone as 16-OHE1 and 4-OHE1. You want to convert these forms into healthy forms of estrogen via the COMT enzyme and CYP1A1. Supporting healthy estrogens here requires:
Support your partner's healthy fertility as well with Optimal Man. He would take 2 capsules after breakfast and 2 after lunch to support healthy sperm and healthy chromosomes.* In health, |
| Hello, how do you recommend taking this product with testosterone? Husband has low testosterone and high estrogen. | Hi Theresa - This is a common situation. To support your husband, consider:
This combination is very supportive of healthy estrogen and testosterone levels.* He can retest in 2-3 months time. He should notice changes within a week at the latest. In health, |
| Hi Dr Lynch, I am desperate to find some relief for my wife from her chronic migraines (which has really negatively impacted our quality of life) which we feel like are hormone and stress related due to classic symptoms of high estrogen levels such as heavy periods, migraines, breast tenderness around period, acne around period, etc. I know there's a lot of talk about the different detox phases / pathways. Would this product be helpful for her? I'm also thinking about getting her started on Optimal Magnesium (she's been taking a magnesium I threonate for a while) and the Glutathione Plus Lozenges. | Hi Paul - I hear you. Migraines must suck. Let's help her out. Consider:
She may also need Histamine Digest if she's eating foods high in histamine. The high histamine aggravates blood flow in the brain leading to migraines. Histamine Digest supports healthy histamine levels.* High estrogen also promotes histamine so by supporting healthy estrogen levels above, she's also supporting healthy histamine levels which is why I'm only stating Histamine Digest as a 'consideration.'* High estrogen can increase stress due to heightened dopamine levels. If she's still stressed after supporting healthy estrogen levels, then she may need Stress Nutrients or Lithium Orotate and take on days she needs support for a healthy stress response.* These should help her a lot and within a few days I suspect. In health, |
| Is this ok to take if I also have SIBO? I recently took a urine mycotoxin test and came back high in zearalenone and DON. Zearalenone can cause high estrogen levels. I was curious about taking DIM for the mold issues but I also have SIBO so and too many cruciferous veggies make me bloated and uncomfortable. | Hi Mae - I'm glad you asked. I have better options for you to consider:
This combination supports a healthy gut microbiome, supports healthy gallbladder and bile production and flow and support healthy detoxification of mold.* I highly recommend sauna as well: In health, |
| Looking for something to treat hormonal acne in 20 year old girl. How often should this be taken? Are there any side effects to be concerned about? Thank you! | Hi Kim - I like your choice here. Consider supporting healthy skin with:
We don't want to lower estrogen levels too much as that leads to dry skin, poor focus, low mood to name a few. In health, |
| I have elevated estrogen (high-risk) and increased anti-TG(thyroglobulin), along with hypothyroid symptoms. Is it safe for me to take this health supplement ? | Hi Lily - Yes and it's supportive of healthy estrogen levels so I do suggest you consider taking 1 capsule after dinner.* You may also want to add in 1 capsule of Calcium D Glucarate to further support healthy estrogen levels.* You can take both capsules at the same time after dinner. In health, |
| Hello, Is this DIM perhaps contraindicated with blood pressure meds such as Metoprolol? Thank you. | Hi Diane - No contraindications here. I do recommend you consider in addition to support healthy blood pressure - and can be combined with your blood pressure medications:
In health, |
| I am homozygous for all three CBS mutations so I have issues with sulfur. Almost half of my estrogen pushes down the 16-OH pathway (47%) according to my DUTCH test. Should I take DIM to help move estrogen down a healthier pathway and then take molybdenum to counter effect the sulfur in the DIM? Thank you in advance! | Hi Marie - I'm glad to hear you did the DUTCH test - that's a great one. To support your estrogen, consider:
In health, |
| Hi I’m 50 and suffering from perimenopause symptoms. My testosterone tested extremely low for my age and estrogen and progesterone tested pretty low normal. I’m not doing well on testosterone bioidentical cream but not taking anything else other than your optimal multivitamin. I am homozygous 1298 mthfr is this product for me? | Hi Cassidy - I hear you. DIM+I3C is not the right supplement for you. Consider:
These should help you quite quickly - in a few days or so. In health, |
| Hi, I used to take Dim as I always had oestrogen dominance and severe pms symptoms. Now I am 46 and my latest hormone test has seen a drop in oestrogen and progesterone. I have very difficult pms symptoms still with inflammation and uterus pain and cramps starting 2 weeks before my meses. Will Dim bring my oestrogen levels down further or just detox the unhealthy oestrogen? | Hi Louise - Great question and I'm glad you asked. I'd approach this from another angle. Hormone testing is interesting because hormones, as you know, move all over the place as a woman. Depending on when you tested, they may be high, and then another day you may test when they're low. During ovulation, estrogen spikes. During menses, estrogen is very low. It makes sense you're having pain 2 weeks before menses which is when your estrogen spikes. Here are some things to consider:
In health, |
| Can I safely take DIM along with Lithium Orotate? Do they compliment each other well? I'm not certain if I have any MTHFR gene mutations, but do have ADHD. | Hi Trisha - You may, yes. ADHD has three types - so not sure which one you're experiencing.
Low dopamine is associated with inattentive type. Consider 1-2 capsules of Dopamine Nutrients to support healthy dopamine levels.* Low acetylcholine is associated with hyperactive type. Consider 1-3 capsules of Optimal Focus to support healthy acetylcholine levels.* If mixed, consider 1 capsule of each. In health, |
| Hi can we use this and or calcium glucorate in menapause. I was estrogen dominant but now all my hormones have tanked. I have used dhea but for hormones thats all. I have phase 2 detox issues and highish cholesterol, always congested stuffy watery eyes and allergies, do not digest fat well or absorb vit d. I take dha, omega 3s and just started udos 3, 6,9. Since menapause i crave healthy fat and my brain loves it, just dont seem to digest it well, use standard process cholacol and or lypo gold. also prescribed 25,000 vit d with k2. Thanks. Lori Clinger | Hi Lori - I would be careful using either DIM+I3C or Cal D Glucarate if your estrogen levels are low. I hear what you're saying and it makes sense. I have solutions for you:
Start here. Keep me posted. In health, |
| Hello, I just had my blood tests done and my Ferritin is 10 (very low - below Canadian norm) and Hemoglobin is also low. I read that B9, B12 and Iron should be supplemented to correct this anemia. Do you agree? With MTHFR and slow COMT what would you recommend? I am 57 y/o woman 125 lbs entering menopause. I experience heart arrhythmia and high pulse rate due to the anemia? Thank you in advance. | Hi Romana - A ferritin level of 10 is quite low. If both ferritin and hemoglobin are low then you need to supplement with iron. I can see how this would affect your heart rate, and most likely your energy as well. Vitamin B12 is needed for iron absorption. A folate deficiency can sometimes mask a B12 deficiency. I would suggest:
All the best! Elizma Lambert (ElizmaLambert.com) |
| Estrogen clearance, on HRT Thank you for your recommendations. So, you think I need more progesterone because I was unable to tolerate DIM. I am already taking Lithium Orotate, (5mg, twice daily), but I read to use caution when taking it with St John’s Wort (serotonin syndrome). SJW also inhibits CYP1A2. It looks like ElizmaLambert is based in Australia. As a naturopath, can she prescribe medication, i.e. HRT? Thank you! | Hi Anne - Elizma is unable to prescribe medication. You would need to find a health professional who can assist you. She can help guide you though more precisely than I can and suggest if she thinks you need it or not. I am not sure if more progesterone is the answer if you cannot tolerate DIM. When it comes to hormones, it's best to be monitored and guided. I don't want to give you poor information. In health, |
| Hi Dr Lynch, I am still reading through Dirty Genes but have had several genetic tests done with functional doctors and have been prescribed many supplements but the results is a little confusion and I don't feel any difference from taking them. I feel I have always been estrogen dominant - I have melasma from Yasmin Pill (stopped 17 yrs ago), store weight on my hips and back of arms, breasts, have fibrous breast tissue and some lumps, have had uterine fibroids but they went without needing surgery (I took serrapetase). I do lack energy and find it hard to lose weight. I am sensitive to fragrance have thin hair and low iron. I am 42 years old. My gene tests say due to my results I could be high risk for breast cancer and so I want to make sure my methylation is supported and estrogen pathways can clear the 'bad estrogen'. I was also told to be worried about the absence of the GSTM1 gene and take high doses of DIM. I don't want to overdo things but also am concerned to not support my detox pathways. I have MTHFR 677 CT, MTHFD1 1958 GA, MTRR 66 GG, COMT 472 AA, COMT H62H TT, COMT V158M AA, no GSTM1 (deletion/none present), IL-1, BCO1 GG (so I will order your vitamin A drops) , COL1A1 GG (I have torn cartilage in my hips so will order your joint supplement) I was also told Grapefruit has been shown to inhibit both CYP1B1 and CYP3A4 enzyme activity so I should take that but I understand grapefruit can interact with supplements and meds (not on any meds). I was told to encourage CYP1A1 over CYP1B1 and CYP3A4 hydroxylation with DIM and green tea. But green tea may not be good for my COMT? Please can you advise if this DIM supplement is for me and any others. I have never taken Glutathione but take a general B complex, PC and your electrolytes. THANK YOU | Hi Candice - Sounds like you've done quite a bit of research and on point with a lot of your statements. I'd like you to work with a health professional so you get a baseline of what your actual hormone levels are vs just taking a lot of DIM and other things. It's not just about taking DIM either for healthy estrogen levels - there are three types of estrogen that must be watched. E1, E2 and E3. Methylation is key and I see you have some COMT and MTHFR snps which can increase the harmful estrogens - so be good to see those. And you should measure your homocysteine as well. Consider:
In health, |
| Hi Dr. Lynch, I tried a lower dose of DIM (100 mg) yesterday to start and within two hours was absolutely soaked, then chilled, then not feeling so great. I am hesitant to start the higher dose. Also taking liver nutrients, calcium d glucarate and PQQ. On HRT but having estrogen clearance problems (COMT-guesstimated as fast but acting very slow, raw data missing), MTHFR (slow, A1298C, one copy), CYP1A2 (indeterminate speed, +/+, CC). Can you tell me which one of your recommended practitioners would be a good match. I am overmethylated/anxious (intolerant of Methyl B12, Glutathione, SAMe). Thank you - Anne B. | Hi Anne - I suspect your progesterone levels need some looking at and support. COMT support if acting slow can be a methylation issue and/or a magnesium deficiency. I'd say Lithium Orotate or Stress Nutrients can be quite supportive of a healthy mood for you. ElizmaLambert.com is great to work with ;) In health, |
| Hi Doc, I’ve had perioral dermatitis for about a decade and am constantly struggling to find out what’s causing it. The only times it has ever cleared up have been after childbirth and then within a few months it comes right back, therefore I think it’s a hormone issue. Could DIM + IC3 help with this? Also, is it safe to take while breastfeeding? Thanks in advance for your help. | Estrogen does increase histamine production and release. Consider:
These are safe to take while breastfeeding. Keep me posted. You should notice some changes within a week. In health, |
| Hi, I am interested in supplements for estrogen clearance. I am presently taking calcium d glucarate (250 mg) and PQQ (20 mg). Looking at DIM/IC3 but am very sensitive to medications. Would you recommend Skin Nutrients to start at a lower dose? Also want to mention that I am overmethylated (intolerant of glutathione and Methyl B12). Thanks, Anne B. | I'd use the DIM+I3C over the Skin Nutrients. Take 1 capsule after dinner. Additionally, consider:
In health, |
| Thank you so much dr. Lynch. I will implement your suggestions right away. I am in Western Canada so have to get these supplements here first. With MTHFR and Slow COMT/MAO (10 cm - 4 inch uterine fibroid): - Should I continue with Folinic Acid (I take 1/2 in the morning) - Any other B vitamins I should take? - Is paleo/carnivore diet recommended to up my protein intake or to eliminate fiber and reset my microbiome (I would rather do a juice fast than eat a lot of meat) hence my question. I am blood type A - should I drink green tea to speed up my COMT? - can I continue to eat cruciferous vegetables (I eat a lot of them fresh, steamed and fermented) instead of taking DIM/I3C? - should I eat less volume more often or bigger meals less often? Thank you for helping me dr. Lynch. Your book has opened my eyes and explained so much of my life :) I was always a very high achiever and now do not feel like myself anymore. Hopefully I will be able to balance it all out and avoid hysterectomy. | I'd follow the considerations I shared prior. There are reasons why I mentioned those vs the other ones you suggested. The meat is highly recommended vs plant based as the plant based is not working and may be actually harming. Green tea slows COMT - doesn't speed it up. If you'd like more guidance, please reach out to ElizmaLambert.com In health, |
| Can I take 2 @ day safely? | You may if your estrogen levels are high as it supports healthy estrogen levels.* If you don't know what your estrogen levels are, I recommend taking only one and testing. You may also find that you only need to take it for a week prior to menses then stopping. If estrogen levels get too low, bones get weak, moods drop, heart health can struggle and skin and vaginal mucous membranes get too dry. In short, DIM+I3C can be taken 2 a day safely if there is a need and then I would adjust how much you are taking based on labs and symptoms and what your health professional advises. In health, |
| Hello, I have read Dirty Genes and determined that I have MTHFR snp as well as Slow Comt. Last year within 12 months I grew a 10 cm (4 inch) uterine fibroid. I am 5'6" 122 lbs and eat super clean, organic and healthy with minimal wild/grass fed animal proteins, drank some green tea, use no chemicals or plastics, intermittently fast. I was shocked being diagnosed with this problem. Since I want to avoid the surgery I am researching what I should do to shrink/eliminate this fibroid. I suspect plant phytoestrogens raise my estrogen and eating a lot of flax, cumin, fennel, cruciferous vegetables, taking high dose Niacin (~3 grams per day), high dose Vitamin C (~6 grams per day) have contributed to the growth. I have since almost eliminated animal protein and eat a very low fat, plant based, mostly raw, organic diet, stopped taking high doses of Niacin and Vitamin C, eliminated caffeine, trying to de-stress, eat lots of leafy greens and some beef liver. I drink H2 water, home made vegetable juices and green shakes, take 20,000 IU of Vitamin D3 per day, K2, Folenic Acid (yours) and AOR B Complex, Mg. I hydrate in the morning with water and vegetable juices then eat 2 meals within 6 hours to be done eating by 6 pm and go to sleep at 9 pm. I have no problems falling asleep. What should I add to this protocol dr. Lynch? I would greatly appreciate any advice or direction you can point me to. | I believe you summarized some major contributors to fibroid growth. Consider:
This should support healthy estrogen metabolism and detoxification of estrogen.* In health, |
| Hi Dr Lynch, we've been playing around with a few of your supplements for my 16 year old daughter based off your previous recommendations. You give me hope that we can find a regime that will work for her (although she feels very little hope at the moment :-(...What we know from my reviewing her 23andme SNPs: Homozygous COMT, MAO, DAO, GST Hetero MTHFR, PEMT, NOS3 Unknown. I think a big part of her challenge is hormonal imbalance hence I have bought some of this product but thought I would check with you first. I notice a difference when she takes lithium in her ability to focus; she was taking 1/2 glutathione then she stopped it; she is taking stress nutrients on and off (I am trying to get her to take this daily) and she was taking gallbladder nutrients but her stomach is gurgling/cramping a lot at the moment. I am trying to get clear in my head around a good option moving forward. We have had some smaller wins with your supplements with both the lithium and histadigest products being useful so just wanted to make sure there wasn't anything you think I need to be aware of before tyring her on this. thanks | Glad you're getting some wins. Here's some thoughts to consider:
Let's try these. She should notice an improvement quite fast. I don't want to use too much DIM for her which is why I recommended the above - it's more gentle and more comprehensive. In health, |
| Hi! I have suspected insulin resistant PCOS after getting off the birth control pill 13 months ago. I have irregular periods and have had two in the past 13 months. I have been gluten-free since mid July and that triggered my first period (so we think). I have been taking this supplement for almost a month now because my functional doctor says I cannot be without a DIM supplement. I struggle with acne so i have been taking skin nutrients and that seems to be helping a lot! Ive also introduced gallbladder nutrients. I know that you recommend taking myo-inositol at 3g but I am curious what brand or formula you would recommend. I have struggled with constipation for a long time that comes and goes. I take magnesium citrate regularly and drink optimal electrolyte occasionally but I am curious if you recommend anything else to support this. | Well done on going gluten-free and working on getting healthy. It's work! :) If a woman is not getting her menstrual cycle, it's usually for a few reasons - not that many.
Consider:
I'd consider a multivitamin as well - something like Prenatal Essentials MF and take 1 capsule with breakfast. Don't take 2 capsules. In health, |
| Hi there, Im considering taking this for my estrogen dominance symptoms. However, I am seeing that a common side effect is gas and bloating. I already have a gas and bloating problem, so i'm afraid if I take this it might make it worse. But I am still looking for support in getting rid of excess estrogen. | I'd add in a couple things to support you. Consider:
That should help a lot. In health, |
| Hi, I recently started taking this supplement as suggested by my natural medicine Dr ( for endometriosis, fibroids and painful periods). I take it with dinner and it causes a lot of bloating/gas that resolves by the next morning. Is the gas a normal reaction to this supplement? When is the best time to take it (I prefer not to be bloated all day)? Thank you! | Bloating/gas is not an uncommon side-effect of DIM. But I get that it's not pleasant. If you are taking it at dinner and the bloating resolves by the next morning, maybe that's the best time to take it. If it saves you from bloating during the day. You may also try taking Molybdenum with it and see if that reduces the bloating. DIM is a sulfur-based supplement and it may be the sulfur that is contributing to the bloating. Regards, |
| I am interested in taking DIM+I3C but I am currently taking Symplex F by Standard Process. Are there any contraindications if I take both? | There's no harm in taking both if you need to support healthy estrogen levels.* You may accomplish that faster by adding in DIM+I3C. In health, |
| Hi! I’m in my late 30s, and I’ve started realizing mg PMS is stronger than ever. I’ve started taking this supplement daily. However, I’ve also realize that now I have too frequent of a period. I will have a period every 2 weeks or so, light usually, some fatigue with it. Should I stop taking this supplement? Thanks! | You could try taking DIM + I3C maybe every second day and see if that helps to regulate your cycle a bit better. Even at this more infrequent dose, it will still help support healthy estrogen metabolism.* For PMS you could also try Histamine Nutrients, especially around the week or so before your period, or when you experience symptoms. Take 1 capsule morning and night. Histamine can affect estrogen and dopamine levels which may increase PMS symptoms such as irritability, poor sleep, period pain, etc.* Let us know how you go :) Regards, |
| Hello, I am trying to decide if I need DIM or Calcium D-glucarate (spelling?). I have PMS where I'm highly irritable and then a lot of period pain and debilitating exhaustion at the start of my cycle. Sometimes it feels like the PMS irritability lasts two weeks, and the debilitating fatigue hits day 28 and cycle day 1. I have very normal cycles and just experienced a miscarriage, which I believe is related to low progesterone, and having a dirty and slow DAO gene (thanks to your histamine pathway helping me discover), that seemed to kick into high gear after Covid and led to hypermobility and a ton of sensitivities. I have heterozygous MTHFR (A version), slow PEMT, and intermediate COMT and intermediate MAOA. I am currently taking all of the Histamine supplements you all sell, plus your prenatal, adrenal cortex, and stress nutrients, and liver nutrients, and Gut nutrients powder, ox bile, Optimal PC, Glutathione Plus, your dopamine supplement and brain nutrients (either dopamine or brain nutrients seems to be causing diarrhea?) ... (I'm waiting on the gallbladder nutrients to arrive). This didn't seem to help with the PMS though (to be fair I've only been on the supplements for a couple of weeks), so I'm comparing the estrogen supplements. I'm wondering if estrogen is driving the histamine. I've treated lyme and mold and seem to be past all of the covid symptoms. Now I'm left with brain fog, exhaustion, waking around 3am and 5:30 am, symptoms that seem like hEDS (maybe histamine related hypermobility??), and a very reactive gut that reacts to non-histamine foods more than histamine-heavy foods. (Sorry for the long story, but I want to give the full picture) | DIM+I3C is what you need based on your symptoms. This is a big missing factor for you. Here are some things that may help your mood:
Try these changes and keep me posted. In health, |
| ’ve taken DIM in the past and I could feel it help with balancing me but caused me to have migraines. Is this supplement something I should avoid or is this a formulation I should try | Hi Brittany - DIM is a sulfur compound. High sulfur can contribute to sulfites which may lead to migraines. Also, large estrogen fluctuations can also trigger headaches and migraines. Perhaps you were taking too much DIM. Consider only taking DIM+I3C say on Day 8 through Day 15 or so. In health, |
| Hi, I was wondering if you could make some sense of this. I struggle with terrible histamine reactions. I'm taking Histamine Digest and ProBiota HistaminX. They are both helping along with a low histamine diet. I'm also having some pretty terrible PMS. Ovulation is very painful then I turn into an angry, frustrated, very impatient person which is not my norm at all. I tried Progesterone and it seemed to make things worse. I just started DIM and it seems to be working. My mind feels more stable and calm. My doctor keeps wanting to put me on Prozac because she seems to think I am having terrible PMS because of low serotonin. If the DIM is working, that wouldn't be the correct move? Also, when I take any sulfur based supplements like DIM or NAC, within the hour of taking it I feel like I can breathe so much easier. Is that a normal thing with those kinds of supplements? Shortness of breath is a huge histamine symptom for me and it goes away when I take these supplements. | You're correct. Your doctor is incorrect. You're addressing an underlying cause of high estrogen which needs support by using DIM+I3C to support healthy estrogen levels.* PMS is often due to high estrogen not low serotonin. It is also normal to experience improved breathing when supporting healthy estrogen levels. Why? High estrogen stimulates histamine release - in other words, high estrogen increases mast cell activation. Keep in mind that you should stop using DIM+I3C once you are feeling good and only reintroduce it when needed again. Too low of estrogen will lower your mood, lower your libido, lower your memory and drive. Use supplements when you need and stop when you feel great. In health, |
| Hi, I was wondering if you could tell me about the bioavailability and absorption of your DIM. I was reading some articles and learned that, apparently, DIM is extremely insoluble, and has low bioavailability and poor absorption. Is there anything you do (technology, features of your product or what’s different) to increase the bioavailability and absorption of your DIM? Thanks! Stacey | Hi Stacey - That's a good question. Many ingredients have pretty poor absorption which is why one needs to take more of that ingredient in order to offset the poor absorption. Iron, calcium, collagen, protein, trace minerals, glutathione, NAC, creatine, etc Our customers experience results from our DIM+I3C and our other products. I can say with confidence that despite reduced absorption for many of these nutrients, they perform as we use them in the right amounts and with a delivery system that is quite effective. I personally use our DIM+I3C as does my wife and we notice improvements same day of using it. In health, |
| I was recently recommended to take this due to an imbalance of estrogen and progesterone. This makes me extremely tired/fatigued, pressure in my head and brain fog. Is this typical? Why these symptoms and can I adjust? | This may be two reasons off the top of my head:
You will know if you have too much sulfur if your breath smells like sulfur, your gas or your armpits or stools or urine.
Estrogen supports healthy histamine levels and healthy dopamine levels. If you're not eating sufficient protein, or absorbing it, then your dopamine and histamine levels may be too low. Make sure you are eating, and absorbing, sufficient protein. Consider Digestive Enzymes with your meals, chew your food very well and make sure you are getting sufficient protein - about 1 gram per 2 pounds of body weight.
In health, |
| I'm homozygous for the MTHFR gene. My gynecologist warned me not to take natural progesterone or bioidentical hormones to treat menopausal hot flashes because she views the MTHFR gene mutations as a bleeding disorder. Is this true? Would DIM + I3C be a safe product for me to use? | I'd say partially. With MTHFR variants, it's important to monitor and be mindful with hormone replacement therapy. It's not a contraindication. I'd look into the progesterone creams on Amazon - they seem to be really helping women. DIM+I3C is helpful to support healthy estrogen levels if estrogens are high.* Some times estrogen levels are high because progesterone levels are low. So look into those progesterone creams. I'd also have your doctor do a DUTCH Urinary Hormone Test. It's a pain to do the urine collection but it's a great test. In health, |
| After a breast cancer surgery could this supplement be used in place of a an Estrogen recepter drug used to eliminate a reoccurence of breast cancer? | An estrogen receptor blocking drug acts on blocking the estrogen receptor. DIM+I3C works by supporting healthy estrogen levels.* They are not the same. A combination of them may be useful. Talk with your doctor. Be sure to have your doctor evaluate your Estrogen Fractionation Test. This shows your levels of E1, E2 and E3. Some estrogens are beneficial and others are harmful. Using the DUTCH hormone test is also helpful. In health, |
| Dr Lynch, I remember you were saying once that your wife takes DIM but it can sometimes maker her a little sad or weepy so she takes another supplement along with it to balance her out. Can you tell me what that supplement is? I am experiencing irritability and wonder if it could be related to the DIM. When I don’t take it, I feel less irritable. I do have estrogen dominance so I need it. | Lithium Orotate makes my wife a bit weepy if she takes too much. If you lower your estrogen levels too much, that drops your dopamine, too. Usually low dopamine makes people sad and weepy and unmotivated - but sounds like that's not you. I'd make sure you are looking at your cycle and possibly timing your use of DIM+I3C to the estrogen spikes - which are start right before ovulation and last to the end of it. So from day 1 of menses, usually about day 7 to day 14 you would take the DIM+I3C. From Day 1 to 6, you would not use DIM+I3C. Then from Day 16 to 24 or so, there's a bit of a bump in estrogen again and you may want to take DIM+I3C then. I'd also look into taking Stress Nutrients to support a healthy stress response.* It really can take the edge off in a subtle way. Other people will notice your calm demeanor before you do. This you can take daily as it's mostly adaptogenic herbs. In health, |
| Hello, My Dr. recommended taking DIM+I3C to support healthy estrogen levels. I began taking it last week for 2 days. I began experiencing GI issues (tightness in abdomen, loose stools). I have not taken it for 5 days yet I'm still experiencing the same symptoms. Thank you, | This is due to DIM being a sulfur compound most likely. You may have liver or gallbladder congestion - or both - along with a microbiome that is producing higher levels of hydrogen sulfide. This is fairly common. High hydrogen sulfide levels contribute to loose sulfur smelling stools. Talk with your doctor to consider pausing DIM+I3C. Switch to Gallbladder Nutrients. Take 2 capsules before dinner for a few days. You want your stools to be well formed, sink and easy to pass. If needed, consider 2 capsules before lunch and 2 before dinner. Also, talk with your doctor about switching from DIM+I3C to Calcium-D-Glucarate for a month. This supports healthy glucoronidation of estrogens and sulfur compounds.* You would take this any time of day likely at dinner time. I'd also consider Molybdenum capsule - just 1 with dinner. This supports healthy sulfur metabolism as well.* ProBiota HistaminX taken after dinner may also support a healthy microbiome which does seem needs support.* In health, |
| Will this help shrink fibroids? | Fibroids are associated with elevated estrogens from xenoestrogens (chemicals in the environment like BPA), fat, slow metabolism of estrogen hormones in the body due to sluggish detoxification to name a few. Supporting healthy estrogen metabolism is needed. One can support healthy estrogen metabolism by using a capsule of DIM+I3C along with either Liver Nutrients or Calcium-D-Glucarate - depending on how much support is needed.* I'd start with DIM+I3C and Liver Nutrients. Gallbladder is often overlooked and this is often a problem in women over forty, fertile and overweight. Even if you don't have your gallbladder, using Gallbladder Nutrients is supportive of healthy bile production and bile flow.* This is needed to support healthy estrogen metabolism. Start with DIM+I3C and see how you do. The other supplements are suggested if needing more support as estrogen levels may need more support from multiple angles. In health, |
| On the back of the bottle it says "This product contains a mixture of 2 dietary indol 3 - carbinol 13 c and DIM since 13c undergoes biochemical transformation to related indole metabolites, broad spectrum indole may be present upon ingestion.- What does this mean? | Essentially that is information that only real geeks want to know. We will remove that if we haven't already. What that means is you are getting additional benefits by using the combination of I3C with DIM vs DIM alone. Your microbiome converts I3C into other beneficial indoles which do other beneficial things. :) In health, |
| Can this affect PMS symptoms negatively? Can it cause estrogen to get too low or throw hormones out of balance? | DIM+I3C supports healthy estrogen levels. You want to monitor your estrogen levels yes. I would take DIM+I3C if you want to support a healthy mood if PMS is an issue. If you're not experiencing PMS, then do not take DIM+I3C unless your health professional states otherwise or your estrogen levels are high. Calcium D Glucarate is the one you need to be most mindful of. Cacium D Glucarate supports healthy glucoronidation. This pathway breaks down estrogen more than DIM+I3C. In health, |
| I’ve been having issues with spotting since titrating my estradiol patch up to .075. I’ve now reduced my dosage to .0375, but am still spotting. I’m on 300mg of progesterone. I had fibroids removed when I was 48 (I’m now 62) Would this supplement help balance my hormones and possibly stop the spotting? I’m homozygous MTHFR, COMT, and PEMT. | I'd measure your homocysteine levels. I suspect they are higher than they should be. Consider Homocysteine Nutrients with breakfast. When it comes to supporting balanced hormones, this is tricky and must be managed with your health professional. You are correct that DIM+I3C supports healthy estrogen levels - and that high estrogen is associated with spotting and fibroids. I would consider taking DIM+I3C at night. That said, do not guess. Measure. You want to ask your health professional to order the DUTCH urinary hormone test. Liver Nutrients OR Gallbladder Nutrients would be another recommendation. I'd start with Liver Nutrients to support healthy liver detoxification. Take 1 capsule with dinner. In health, |
| Hello, Thank you for answering my previous questions.. 2 more questions.If Gallbladder support is not helping the constipation, adding calcium d glucarate could? If I am sensitive to sulfur (sulfa medication allergy, can't tolerate eggs) is it okay to take DIM+IC3? Thank you,Tania | Constipation has many factors at play. Low stomach acid Calcium D Glucarate is definitely a great option to support healthy bowel movements. I'd also add Serotonin Nutrients before bed - especially if you are also struggling with not sleeping all the way through the night.* Calcium D Glucarate and DIM+I3C are both supportive of sulfur metabolism so yes they are well tolerated.* In health, |
| Hello, I am currently taking histamine digest and gallbladder nutrients for hot flashes, histamine symptoms and constipation. I also take B complex plus. I have been taking another supplement for perimenopause, broccoprotect for sulfuraphane. It isn't helping much. She suggested switching to broccoprotect to DIM+I3C. Is there any contraindication/interaction between taking histamine digest, gallbladder nutrients,B complex plus and DIM+I3C? Thank you, Tania | The combination you have listed above is great. To give some guidance: Histamine Digest - take with meals that contain high histamine. Don't take it if not eating high histamine foods or drinks Gallbladder Nutrients - take 2 capsules before lunch and 2 before dinner. You want to have a healthy well formed bowel movement that is easy to pass and sinks. Adjust the amount you take based on how much fat you eat and how well your bowel movements are. The better your bowel movements, the less Gallbladder Nutrients you need. Calcium D Glucarate - take 1 after dinner IF needing more bowel movement support. This also supports estrogen metabolism. DIM+I3C - agree that this is better than Broccoprotect. Take any time of day or night with some food. I prefer after dinner - and can take with Calcium D Glucarate. B Complex Plus - be sure to take this with breakfast or lunch - and not later than 1 pm in the afternoon. Consider Multivitamin One with breakfast and stopping the B Complex Plus. It's more comprehensive. In health, |
| Can this capsule be opened and mixed into food? | It can but it will smell and taste very sulfury. You will have to use a powerful food to mask it. It's pretty gnarly stuff. In health, |
Hello! Can I up the dose if and when I start to feel estrogen related PMS symptoms? I currently take 1 pill in the AM and 1 in the PM. Or is it ok to up the dose daily to 1-2AM and 1-2PM? | Absolutely. Take as needed any time of day or night. I'd also consider Lithium Orotate if you are feeling a need to support healthy response to stressors - if that feels uncontrollable. Only use during those times and stop when you feel already in balance. In health, |
| can i take this if i have hashimoto throid | Yes you may ;) IF you need to support healthy estrogen levels. In health, |
| Is this suitable for a 16 year old girl? | DIM+I3C supports healthy estrogen levels. If she needs to support healthy estrogen levels, then yes, it is recommended. High estrogen levels contribute to undesirable moods, more painful menses and increased bloating and tenderness to name a few. Consider taking 1 capsule as needed especially during days 10-17 of her cycle when estrogen naturally rises. Other keys to consider:
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| Are there any cardiac interaction concerns? I take baby aspirin daily to thin my blood and would not want any adverse side effects, but this product was recommended by a friend for perimenopausal/menstruation issues... | Healthy estrogen levels support a healthy heart. Low or high estrogen levels do not support a healthy heart. Estrogen levels must be balanced - not too low or too high. Taking a baby aspirin daily tells me you may want to consider Optimal GI capsules or Gut Nutrients powder. Take upon waking in the morning or before bed at night to support a healthy gut lining. Aspirin is very tough on the stomach. In health, |
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